Depression Treatment, Diagnosis, & Causes
Clinically Reviewed by Lauren Barry, LMFT, MCAP, QS
Medically Reviewed by Ali Nikbakht, PsyD
Updated on September 12, 2025 — Editorial Policy | Research Policy | Privacy Policy
By We Level Up | Editor Yamilla Francese | Editorial Policy | Research Policy
Do I need Depression Treatment?
Depression can be a tough condition. You may struggle with it for your whole life if you don’t ask for help. If you battle with symptoms of depression, there is help available. At We Level Up, we offer depression treatment programs to help you get your life back.

Understanding Depression
The National Institute of Mental Health states that depression affects approximately 17.3 million adults in the United States. Depression is a serious mood disorder that affects how you feel, how you act, and the way you think. It causes a persistent feeling of sadness and can affect your ability to perform everyday activities.
Learn More:
- Understanding Clinical Depression
- Alcohol and Depression: A Strong Co-occurring Connection
- Bipolar And Addiction
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- Cocaine and Depression
- Benzos and Depression
- Depression and Substance Abuse Comorbidity
- Rehab for Depression
- Hyperbaric Oxygen Therapy for Depression
- Neurofeedback Therapy for Depression
- Can You Go To Rehab for Depression?
- Severe Depression Treatment
- Depression Hospital
- Women’s Depression Treatment Center
- Residential Treatment for Depression
- Inpatient Depression Treatment
If you have imbalanced chemicals that affect thoughts, moods, appetite, sleep, and behavior, you may have a higher risk of developing depression. If a close relative suffers from depression, you are also more likely to have this condition because there is a genetic factor involved in its development. Your brain’s structure can also impact your chances of developing depression. Having a frontal lobe that is less active than normal is associated with suffering from a major depressive episode.
Substance use, as well as certain medical conditions, are also risk factors. Suffering from insomnia, chronic illnesses, cancer, and other conditions can affect your chances of developing depression.
Some of the symptoms of depression include:
- Feeling sad or having a depressed mood
- Loss of interest
- Changes in appetite
- Trouble sleeping or sleeping too much
- Loss of energy or increased fatigue
- Unexplained physical problems, like back pain or headaches
- Feeling worthless or guilty
- Difficulty thinking, concentrating, or making decisions
- Thoughts of death or suicide
- Angry outbursts, irritability, or frustration, even over small matters
- Loss of sexual desire
In order to receive a diagnosis of depression, these symptoms must be present for at least two weeks. Depression can affect anyone, no matter their age. However, it often starts during the teenage years.
There are different types of depression, and they each require specialized treatment. They include:
- Major depressive disorder (MDD)
- Persistent depressive disorder (PDD)
- Bipolar disorder
- Postpartum depression (PPD)
- Premenstrual dysphoric disorder (PMDD)
- Seasonal affective disorder (SAD)
To help them deal with the symptoms of depression, many people turn to substances like alcohol and drugs. Although it may seem as though these substances help manage depression, they can actually make depression worse. A substance use disorder can trigger or intensify feelings of sadness, hopelessness, and loneliness. Drugs and alcohol also affect your body’s natural dopamine production, making depressive symptoms worse.
Depression is a serious condition and can progress when left untreated, leading to complications. These can include:
- Family conflicts, relationship difficulties, and work or school problems.
- Self-mutilation, such as cutting
- Premature death from medical conditions.
- Pain or physical illness
- Anxiety, panic disorder, or social phobia.
- Alcohol or drug misuse
- Excess weight or obesity can lead to heart disease and diabetes
- Social isolation
- Suicidal feelings, suicide attempts, or suicide
Understanding that depression can lead to physical health issues can encourage someone to get help. This can also motivate them to make changes to manage their symptoms.
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7/365 Line (844) 597-1011Treatment for Depression
At We Level Up, we offer depression treatment programs to help you with the mental health challenges you face. Treating depression is a complex process. It needs a complete medical assessment. This helps to make sure there are no physical causes for how you feel. At our center, we do a thorough intake assessment. This helps us understand your type of depression and any other disorders you may have.
We offer medications to help treat depressive disorders. This is particularly helpful if a chemical imbalance in your brain is involved in your disorder. Some of the most common medications we provide for the treatment of depression include:
- Selective serotonin reuptake inhibitors
- Atypical antidepressants
- Serotonin-norepinephrine reuptake inhibitors
- Tricyclic antidepressants
- Monoamine oxidase inhibitors
The experts in our depression treatment programs often start by prescribing SSRIs. These medications usually have the fewest side effects. Our team of medical experts can help you look at your options. We will find the right medication to treat your depression.
Medications alone may not be enough to help with severe depression, however. Talk therapy and other proven treatments are used with medications to get the best results. Behavioral therapy is the gold standard for the treatment of mild to severe depression.
We offer cognitive-behavioral therapy. This therapy helps you see how negative thoughts affect your feelings and actions. You can learn to identify these negative thoughts and change them before they affect your mood. Cognitive-behavioral therapy also helps you understand the motivations of others, giving you greater insight into your interpersonal relationships.
At We Level Up, we provide dialectical behavior therapy (DBT) to treat major depression and other depressive disorders. DBT can help you increase interpersonal effectiveness while also teaching you how to regulate intense emotions and distress. DBT can also help you develop mindfulness skills.
Interpersonal therapy is another excellent therapy option we offer at We Level Up. It aims to reduce depression symptoms by improving your relationships now, not by focusing on past issues.
At We Level Up, we provide group therapy, support groups, family therapy, and individual sessions. These services help you learn how to use the techniques you have learned. For those who lack the motivation to start healing, we also offer motivational interviewing.
We know that clinical depression can impact many parts of your life, including your self-esteem. That’s why we offer holistic therapies to support you.
Treatment-resistant depression is one of the most challenging forms of severe depression. It does not respond as well to medications or talk therapy as other types of depression. If you have treatment-resistant depression, we will work with you to put together a treatment plan that offers relief for the worst symptoms.
At our center, expert mental health professionals can help you with depression treatments that can improve your condition.
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Even if you have failed previously and relapsed, or are in the middle of a difficult crisis, we stand ready to support you. Our trusted behavioral health specialists will not give up on you. When you feel ready or just want someone to speak to about therapy alternatives to change your life call us. Even if we cannot assist you, we will lead you to wherever you can get support. There is no obligation. Call our hotline today.
(844) 597-1011Benefits of Inpatient Depression Treatment
At We Level Up, we recommend inpatient treatment for those struggling with moderate to severe depression. Staying at our facility gives you a safe and supportive space. You can escape any problems at home that may affect your mental health.
People who are at risk of harming themselves can benefit greatly from staying in an inpatient setting. Inpatient programs allow you to immerse yourself in treatment and have 24/7 medical support. Our providers are there to monitor and address any side effects and keep you safe while you recover.
Our inpatient treatment for severe or moderate depression also allows you to feel less alone with your condition. You can join support groups and family therapy sessions. These can help you see that you are not alone.
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Get Depression Treatment Now
If you struggle with depression symptoms, it is important to get help. At We Level Up, we provide top medications and therapy options to help you manage your mental health.
Contact us at We Level Up today to begin your recovery.
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Top 5 Dual Diagnosis Studies with Insights
Here’s a patient-friendly chart of the top five Depression Treatment studies/guidelines.
Here is a useful list of trusted studies and guidance on Depression Treatment. You can use these in clinical documents, program pages, or treatment guides. Each row distills what the evidence implies for treatment and turns it into actionable tips for care teams and admissions scripts. Sources were chosen for recency, rigor, and relevance to integrated treatment.
| Study | Treatment Implications | Insights for Patients |
|---|---|---|
| Real‑World Effectiveness of Ketamine in Treatment‑Resistant Depression: A Systematic Review & Meta‑Analysis View Study | A review of 79 studies (~2,665 patients) shows that ketamine is effective in real‑world clinical use. ~45% showed response; ~30% remission. Repeat dosing enhances the effects. | If traditional meds fail, ketamine can be effective, especially with multiple treatments. Not all patients achieve full remission, but many see significant symptom relief. |
| Effect of Treatments for Depression on Quality of Life: A Meta‑Analysis View Resource | Compared CBT and SSRIs: both improve quality of life, but CBT effects tend to last longer post-treatment. | Therapy may lead to longer-lasting life satisfaction gains. SSRIs can help more quickly, but effects may be less stable. Combination therapy might be most effective. |
| Repeated Oral Ketamine for Out‑Patient Treatment of Resistant Depression: Proof‑of‑Concept RCT Read Article | Oral ketamine (1 mg/kg) taken 3x weekly for 3 weeks helped reduce depression symptoms in outpatient settings. | Offers a more accessible alternative to IV infusions. It may be ideal for patients who can’t visit clinics frequently. Effects are cumulative over time. |
| Pilot RCT of Subcutaneous Ketamine in Older Patients with Treatment‑Resistant Depression Read Study | Subcutaneous (under the skin) ketamine was effective in older adults ≥60 years. Multiple smaller doses worked well. | Age is not a limiting factor. Seniors may benefit from lower, safer doses. Monitoring for side effects is key. |
| Neural Connectivity Moderators and Mechanisms of Ketamine Treatment in Treatment‑Resistant Depression Read Review | Brain scans showed that ketamine works by altering frontal‑limbic network connectivity. Certain brain patterns may predict who responds best. | Personalized treatment might be possible soon. Ask providers whether biomarker testing or neuroimaging is available to optimize treatment selection. |
Frequently Asked Questions
What are the most effective treatments for depression?
The best treatments for depression differ for each person. They often include antidepressant medications like SSRIs or SNRIs. Psychotherapy, especially Cognitive Behavioral Therapy, is also common. Some people may try alternative therapies such as Transcranial Magnetic Stimulation (TMS), Ketamine Infusions, or Electroconvulsive Therapy (ECT). A combination of therapy and medication often provides the best outcomes.
What is treatment-resistant depression (TRD)?
Treatment-resistant depression occurs when someone does not respond adequately to two or more standard antidepressant treatments. In these cases, doctors may suggest advanced treatments. These include ketamine treatment, esketamine (Spravato®), DBS (Deep Brain Stimulation), or intensive inpatient care.
Is ketamine therapy safe for depression?
Ketamine therapy is considered safe when administered in a clinical setting under professional supervision. Side effects may include dissociation, increased blood pressure, or nausea—but are usually short-lived. Long-term use should be carefully monitored.
How long does it take for depression treatment to work?
The timeline for relief depends on the type of treatment. Antidepressants usually take 2 to 6 weeks to show results. In contrast, ketamine infusions or TMS can improve mood in hours to days. Psychotherapy often shows cumulative benefits over several weeks or months.


