Percocet Withdrawal: Safe Detox & Recovery Timeline
Medical detox offers a safe and secure facility designed to make the withdrawal process as simple and comfortable as possible. Clients at We Level Up Percocet detox center can focus their entire energy on their recovery without dealing with triggers from the outside world, the temptation to abuse Percocet, or stressors that can weigh on them while they are starting their recovery journey. Read more about Percocet detox symptoms, the timeline, and the best treatment options.
Clinically Reviewed by Lauren Barry, LMFT, MCAP, QS
Medically Reviewed by Ali Nikbakht, PsyD
Reviewed / Updated: September 24, 2025 — Editorial Policy | Research Policy | Privacy Policy
By We Level Up | Author Inês Oliveira, MSc, PhD Candidate | Editorial Policy | Research Policy
What is Percocet Withdrawal?
Percocet withdrawal occurs when you stop taking the drug after long-term use, as your body becomes dependent on the medication over time. This can cause different symptoms. They can be mild or severe. The symptoms depend on how long and how much Percocet is used. Seeking professional medical help is crucial for a safe detox process.
Recovery from Percocet addiction is achievable with a comprehensive treatment plan. This often includes medical assistance, therapy, counseling groups, aftercare programs, and support from your loved ones.
Percocet withdrawal Key Takeaways
Detoxing Off Percocet
- Withdrawal happens after prolonged use → physical dependence + uncomfortable symptoms.
- Common symptoms: anxiety, muscle aches, sweating, insomnia, nausea, vomiting, diarrhoea, cravings.
- Professional medical detox is recommended for safety and relapse prevention.
Percocet Detox Timeline
- 0–12 hours: Early signs (anxiety, sweating, muscle aches).
- 36–72 hours: Peak (nausea, vomiting, diarrhea, chills, strong cravings).
- 4–7 days: Acute phase (symptoms ease, fatigue/insomnia linger).
- Weeks–months: PAWS (mood swings, cravings, sleep issues).
How to Detox From Percocet
- Medical detox with 24/7 supervision.
- Medication-assisted treatment (buprenorphine, methadone).
- Counseling + therapy for emotional support.
- Aftercare: rehab, support groups, relapse prevention.
How Long Does Percocet Stay in Your System?
The length of time Percocet remains detectable in your system varies based on individual factors. However, symptoms are more than just finding Percocet in the body. Knowing the drug’s timeline can help with withdrawal and recovery.
Percocet Withdrawal Timeline
The general timeline for Percocet withdrawal is as follows:
- Within 12 hours of the last dose, early symptoms begin and may include anxiety, muscle aches, and sweating.
- Within 36-72 hours after the last dose, symptoms peak, potentially including nausea, vomiting, diarrhea, chills, and cravings.
- During the subsequent 4-7 days, the acute withdrawal phase lasts, with symptoms gradually subsiding. Less severe symptoms may linger for weeks.
- Several weeks to months: Some withdrawal effects can persist, along with strong cravings. Professional treatment and support are critical during this period.
Ultimately, the severity and duration of withdrawal symptoms can vary from person to person.

Post Acute Withdrawal Syndrome (PAWS)
After the acute phase of Percocet withdrawal, you may experience PAWS, a set of symptoms that can persist for weeks or months. These symptoms are less severe than acute withdrawal but can still affect your daily life. Common PAWS symptoms include:
- Mood swings
- Anxiety
- Depression
- Insomnia
- Fatigue
- Irritability
- Difficulty concentrating
- Cravings for Percocet
PAWS occurs because your brain needs time to rebalance neurotransmitters and adjust to functioning without Percocet. The duration of PAWS varies for each person. It depends on how long and how much Percocet they used.
You can manage PAWS by:
- Attending support group meetings
- Engaging in therapy
- Practising stress-reduction techniques, like mindfulness
- Exercising regularly
- Maintaining a healthy diet
- Establishing a consistent sleep schedule
- Avoiding triggers and high-risk situations
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Your healthcare provider may also recommend medications to alleviate specific PAWS symptoms. For instance, antidepressants can help with depressive symptoms. It’s important to work closely with your healthcare provider during this phase. Remember, PAWS is a normal part of the recovery process.
Don’t get discouraged if Percocet detox symptoms persist; they will gradually improve as your brain heals. Stay committed to your recovery plan and reach out for support whenever you need it.
Percocet Withdrawal Symptoms
When you abruptly stop or reduce your Percocet usage, you’ll likely experience withdrawal symptoms. These can be physical or mental. They can be mild or severe. The severity depends on several factors. These factors include the duration and frequency of substance use, dosage, and personal traits. You can learn more about these factors here.
Withdrawal symptoms typically begin within 12 hours after your last dose, peak around 36-72 hours, and progressively diminish throughout the subsequent 4-7 days. The acute phase usually lasts 7-10 days, while milder symptoms may persist for weeks or months.
Physical symptoms often include muscle aches, sweating, chills, fatigue, and gastrointestinal issues like nausea, vomiting, and diarrhea. Psychological symptoms, such as depression, anxiety, irritability, insomnia, intense cravings, and feelings of restlessness or agitation, can be equally challenging.
In severe cases, you might experience rapid heartbeat, high blood pressure, or seizures, making it dangerous to quit abruptly without medical supervision.
Percocet Detox Protocol
Percocet detox should be conducted under the guidance of a medical professional to ensure safety and effectiveness. Here are some common elements of a Percocet detox protocol:
- Medical Evaluation: The first step in a Percocet detox program is to check the person’s overall health. We check how serious their addiction is. We also check for any other medical issues. This includes mental health problems that need care.
- Medication-Assisted Treatment: Medications like buprenorphine or naltrexone can help manage withdrawal symptoms and cravings during Percocet detox.
- Tapering: Sometimes, a healthcare provider may suggest slowly reducing the Percocet dose. This helps lessen withdrawal symptoms and avoid complications.
- Monitoring: A healthcare provider should closely monitor the individual during detox to ensure safety and support.
- Behavioral Therapy: Behavioral therapy, such as cognitive-behavioral therapy (CBT) or contingency management, can help individuals address the underlying complications that contributed to their addiction and develop coping strategies for managing cravings and triggers.
- Support Groups: Narcotics Anonymous (NA) or SMART Recovery can offer ongoing support and encouragement during recovery.
The Percocet Detox Process
When clients arrive at the We Level Up medical detox center, they will have a complete evaluation. This is for those who are struggling with Percocet addiction. This step helps the medical team diagnose a person’s substance use issues. It also helps them create a personalized treatment plan for withdrawal.
Once a plan is ready, the treatment team will give you specific medications. They will also monitor your progress during your stay. A typical stay at a detox center lasts one to two weeks. It can also last until you feel stable and comfortable in your new sobriety.
Finally, people who have completed detox will have a carefully planned transition of care to an addiction treatment facility. Medical detox is an important first step. However, it should be followed by professional addiction treatment. This helps achieve long-term sobriety and prevents relapse to Percocet use.
We Level Up makes this process easier. We can connect people to our residential rehabs, inpatient treatment options, or a partial hospitalisation program.
Percocet Withdrawal Treatment
Treating Percocet withdrawal requires a comprehensive approach that addresses both physical and psychological symptoms. The best treatment plans are made for your specific needs. They may include medical detox, therapy, and ongoing support.
Medical Detox
Medical detox is the safest way to manage Percocet withdrawal. Your vital signs will be checked by healthcare professionals. They may also give you medications to help with your symptoms. For example, clonidine can help with anxiety and agitation, while buprenorphine or methadone are often used to reduce cravings and discomfort through opioid replacement therapy.
Therapy
Therapy is a critical component of Percocet addiction recovery. Cognitive-behavioral therapy (CBT) helps you identify and change negative thought patterns and behaviors that contribute to substance abuse. Through CBT, you’ll learn coping strategies to manage stress, anxiety, and cravings without resorting to Percocet. Motivational interviewing is another effective therapeutic approach. It encourages you to explore your ambivalence about change and develop motivation for recovery.
Support Groups
Joining a support group like Narcotics Anonymous (NA) can provide important peer support during Percocet withdrawal and recovery. You’ll connect with others who understand your struggles and share similar experiences. This sense of community can help you feel less isolated and more motivated to maintain sobriety.

Aftercare Planning
Aftercare planning is essential for long-term recovery success. Work with your treatment team to create a plan. This plan should include therapy, support groups, and ways to prevent relapse. They may also suggest sober living options or outpatient programs. These can offer extra support and structure in early recovery.
Keep in mind that recovery is a continuous process, not a one-time achievement. With the right treatment plan and support, you can beat Percocet addiction. You can then build a healthier and happier life.
Living with a Percocet addiction can cause serious physical and mental problems. It can make it hard to stop using Percocet by yourself. At We Level Up, our Percocet detox program is designed to help you through the challenging first stage of sobriety.
Percocet Drug Facts
Generic Name: Acetaminophen and Oxycodone
Drug Class: Narcotic (opioid) analgesic combinations
Percocet is a prescription opioid medication. It’s a combination of oxycodone, an opioid pain reliever, and acetaminophen, a non-opioid pain reliever and fever reducer. Oxycodone is a Schedule II controlled substance due to its high potential for abuse and addiction.
Percocet comes in tablet form. It’s available in various strengths, with the oxycodone component ranging from 2.5 mg to 10 mg associated with 325 mg acetaminophen. The usual adult dosage is one tablet every 6 hours as needed for pain.
Common side effects of Percocet include:
- Nausea and vomiting
- Constipation
- Drowsiness and dizziness
- Headache
- Rash and sweating
More serious side effects may include:
- Respiratory depression (slow or shallow breathing)
- Hypotension (low blood pressure)
- Seizures
- Liver damage (due to acetaminophen component)
You should not take Percocet if you have severe asthma, trouble breathing, or other lung problems, a blockage in your stomach or intestines, or a known hypersensitivity to oxycodone, acetaminophen, or any inactive ingredients in Percocet. It’s essential to inform your healthcare provider about all your medical conditions and medications before starting Percocet.
Percocet can interact with other medications, especially other opioids, benzodiazepines, muscle relaxants, and medicines that cause drowsiness. These interactions can lead to dangerous side effects, including respiratory depression, sedation, coma, and even death.
You should never crush, chew, or dissolve Percocet tablets as this can lead to rapid oxycodone release and absorption, increasing the risk of overdose and death. Signs of a Percocet overdose include extreme drowsiness, pinpoint pupils, cold and clammy skin, respiratory depression, and loss of consciousness.
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7/365 Line (844) 597-1011Percocet Addiction Statistics
The statistics below show the serious public health crisis caused by opioid use and addiction. This includes prescription pain relievers like Percocet. People with addiction need to get professional help. This support can help them overcome their addiction and avoid more harm.
9.9 Million
Approximately 9.9 million Americans misused prescription pain relievers in 2019, including Percocet.
Source: NSDUH
50,000
The CDC reports nearly 50,000 people died from opioid overdoses in 2019, including overdoses involving Percocet.
Source: CDC
7%
Roughly 7 percent of all substance abuse treatment admissions in the United States in 2018 were related to prescription opioid addiction, including Percocet.
Source: NCBI
Top 5 Percocet Detox Studies with Insights
Here’s a patient-friendly chart of the top five Percocet detox studies/guidelines.
Here is a helpful list of trusted Percocet detox studies and advice. You can use these in clinical documents, program pages, or treatment guides. Each row summarizes the impact of the evidence on treatment. It turns this information into useful tips for care teams and admissions scripts. Sources were selected based on their recency, rigor, and relevance to integrated treatment.
| Study | Treatment Implications | Insights for Patients |
|---|---|---|
| Profile of Chronic Pain Patients With Opioid Withdrawal Syndrome According to Psychological Factors View Study | Identifies two profiles: Withdrawal syndrome with No Psychological Distress (WNPD) and Withdrawal syndrome with Psychological Distress (WPD). | Understanding individual psychological profiles can tailor treatment approaches. |
| Characterization and Validation of a Spontaneous Acute and Protracted Oxycodone Withdrawal Model in Mice View Resource | Provides insights into the temporal emergence of somatic, hyperalgesic, and anxiety-like behaviors during withdrawal. | Highlights the importance of addressing both physical and psychological symptoms in treatment. |
| Associations Between Pain-Management Treatments and Opioid Use Disorder Risk Among Medicaid Patients Read Article | Co-prescription of opioids with gabapentin or benzodiazepines increases the risk of opioid use disorder. | Emphasizes the need for careful medication management to reduce dependency risks. |
| Psychotic Symptoms Following Oxycodone Withdrawal: Case Report and Update Read Study | Oxycodone withdrawal can lead to psychotic symptoms, including delusions and hallucinations. | Stresses the importance of medical supervision during withdrawal to manage severe symptoms. |
| Percocet Rehabilitation and Treatment Read Review | Advocates for a combination of medical detox, inpatient treatment, and long-term support. | Reinforces the necessity of a comprehensive treatment plan for effective recovery. |

Duration of Percocet Withdrawal Symptoms
People thinking about detoxing from Percocet should get professional help. This support can help manage withdrawal symptoms and improve recovery chances.
Here are some of the common Percocet withdrawal symptoms and the duration they may last:
- Anxiety and insomnia: Can last for several weeks.
- Muscle aches and cramps: Can last up to 2 weeks.
- Nausea, diarrhoea, and vomiting: Can last for several days.
- Abdominal cramps: Can last for up to a week.
- Sweating and chills: Can last for several days.
- Rapid heart rate: This can last for up to a week.
Common symptoms of PAWS associated with Percocet withdrawal can include the following:
- Mood swings: Individuals may experience mood swings ranging from depression to anxiety and irritability.
- Cravings: Even after the acute withdrawal period has ended, some individuals may still experience cravings for Percocet.
- Sleep disturbances: Individuals may experience difficulty falling asleep or staying asleep.
- Fatigue: Individuals may experience low energy levels or fatigue during the day.
- Memory and concentration problems: Some individuals may experience memory and concentration problems during PAWS.
Although Percocet withdrawal generally lasts 5 to 10 days, some people undergo post-acute withdrawal symptoms. PAWS means post-acute withdrawal syndrome. It refers to symptoms that can happen after the acute withdrawal from Percocet is over. PAWS can last weeks or months after the initial withdrawal symptoms have subsided.
Inpatient Percocet Detox For Relapse Prevention
Withdrawal from Percocet and other opioids can increase the risk of relapse. Withdrawal symptoms can be uncomfortable and challenging to manage, leading individuals to seek relief by reusing the drug. Additionally, withdrawal’s physical and psychological effects can trigger intense cravings for the drug. This is why it is crucial to seek professional help when attempting to detox from Percocet.
A medically supervised Percocet detox program can help individuals manage withdrawals from Percocet and reduce the risk of relapse. After detox, ongoing treatment and support are important. They help address the reasons for addiction and create plans to prevent relapse. This can include counseling, therapy, support groups, and medication-assisted treatment.
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(844) 597-1011Percocet Detox Program
During Percocet detox, the body is cleared of the drug, and withdrawal symptoms from Percocet can occur. Percocet is an opioid pharmacotherapy that contains oxycodone and acetaminophen. Oxycodone is a very addictive drug. Stopping it suddenly can cause physical dependence and withdrawal symptoms.
The detox process for Percocet usually means slowly lowering the drug dose over days or weeks. This helps reduce the severity of withdrawal symptoms. This can be done through a tapering schedule under the guidance of a medical professional.
During Percocet detox, the following symptoms of Percocet withdrawal may occur:
- Physical symptoms: These can include sweating, chills, muscle aches, nausea, vomiting, diarrhea, and tremors.
- Psychological symptoms: These can include anxiety, irritability, depression, and difficulty sleeping.
- Drug cravings: A strong urge to use the drug again is a common withdrawal symptom. This can make detoxing hard.
- Medical complications: In rare cases, serious medical complications can occur during Percocet detox, including seizures, cardiac arrest, and respiratory failure.
During Percocet detox, individuals receive medical supervision and support to manage Percocet withdrawal symptoms and ensure safety. This may include medication to ease symptoms, such as nausea or anxiety, and monitoring of vital signs.
Following detox, ongoing treatment and support are typically recommended to address the underlying causes of addiction and develop strategies for relapse prevention. This can include counseling, therapy, support groups, and medication-assisted treatment.
After Percocet Detox
After finishing Percocet detox, it is important to keep getting treatment and support. This helps maintain sobriety and prevent relapse. Detox alone does not address the underlying causes of addiction, including psychological and social factors and physical dependence.
The following are some treatment options that can be helpful after Percocet detox:
- Behavioural therapy can include individual or group counselling to address the psychological and social factors contributing to addiction.
- Support groups such as Narcotics Anonymous (NA) or SMART Recovery can provide a supportive community and accountability.
- Medication-assisted treatment (MAT) can help reduce drug cravings and manage withdrawal symptoms.
- Dual diagnosis treatment addresses co-occurring mental health disorders that may contribute to addiction, such as depression or anxiety.
- Developing an aftercare plan for ongoing support after detox can help prevent relapse. This can include regular meetings with an addiction therapist or support group. It can also involve ongoing treatment and ways to manage triggers and cravings.
Percocet addiction and opioid use disorder are chronic disease that requires ongoing management and support. After finishing Percocet detox, it is important to keep up with treatment. This helps maintain sobriety and achieve long-term recovery. Furthermore, some people experience prolonged withdrawal symptoms of Percocet. The withdrawal symptoms after stopping Percocet need medical monitoring. This helps prevent complications and reduces the risk of relapse and overdose if someone starts using Percocet again.
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How Percocet Detox Can Help
Clients at the We Level Up detox facility receive medical care 24/7. This ensures they are safe, comfortable, and getting the treatment they need at all times. The medical team will make sure all your needs are met. This way, you can focus on feeling better.
There are many benefits to undergoing Percocet detox, including:
- Breaking the cycle of addiction: Percocet detox can help people stop being physically dependent on the drug. This is the first step to recovering from addiction.
- Better physical health: Long-term use of Percocet can lead to various health issues. These include liver damage, breathing problems, and stomach issues. Detoxing from Percocet can help improve overall physical health.
- Reduced risk of overdose: The longer an individual uses Percocet, the greater their risk of experiencing an overdose. Detoxing from Percocet can help mitigate this risk.
- Better mental health: Long-term use of Percocet can lead to anxiety, depression, and other psychiatric issues. Detoxing from Percocet can help improve mental health and emotional well-being.
- Improved relationships: Addiction can strain relationships with friends, family members, and loved ones. By detoxing from Percocet and beginning the recovery process, individuals can start to repair and strengthen these relationships.
- Better quality of life: Recovering from addiction can greatly improve your overall quality of life. This includes better physical health, mental health, and social relationships.
Percocet detox is an important part of recovery for people with opioid use disorder. It can help people stop addiction, boost their physical and mental health, and enhance their overall quality of life.
Start Your Percocet Detox Treatment Today
At We Level Up, our team helps people overcome substance abuse. We support them in achieving lasting recovery. Our Percocet detox can help you take the first steps toward abstinence and a healthier, healthier life in sobriety.
Call our team today to schedule a free, no-obligation consultation or reach out through our contact page for more information about our treatment options. You can break free from Percocet addiction, and the team at We Level Up can help show you the way.
Frequently Asked Questions
Detoxing from Percocet can be a challenging process, but it is an essential step toward recovery. Knowing what to expect can make the experience easier. It can also help you prepare for a smoother recovery. In this section, you’ll find answers to some frequently asked questions about Percocet withdrawal and detox.
How long does it take to detox from Percocet?
The length of Percocet detox can vary from person to person. The body takes 10-15 hours to eliminate most of the oxycodone following a single dose, considering its half-life of 2-3 hours. However, factors like the duration of use, dosage, and individual physiology can impact the detox duration. The full detox process usually lasts several days, during which the body eliminates the drug and its metabolites.
How long does Percocet withdrawal last?
Percocet withdrawal typically lasts 1-2 weeks, with symptoms peaking around 36-72 hours after the last dose. The acute phase lasts 7-10 days, but less severe symptoms may persist for weeks or even months. Early symptoms begin within 12 hours after the last dose, intensifying over the following days. These include anxiety, muscle aches, sweating, and insomnia. As withdrawal progresses, you may experience nausea, vomiting, diarrhea, and intense cravings. Some people develop Post Acute Withdrawal Syndrome (PAWS), experiencing prolonged symptoms such as anxiety, depression, fatigue, and difficulty concentrating. PAWS can last several months, requiring ongoing support and treatment.
How can I detox from Percocet?
The safest way to detox from Percocet is through a professional medical detox program. Attempting to quit abruptly can be dangerous, leading to severe symptoms such as rapid heartbeat, high blood pressure, and seizures. A medical detox provides 24/7 monitoring and support in a controlled environment. Healthcare professionals may administer medications, such as clonidine, methadone, or buprenorphine, to alleviate withdrawal symptoms and reduce cravings. They also monitor vital signs and provide emotional support throughout the process. After detox, transitioning to an inpatient or outpatient treatment program is essential for addressing the underlying causes of addiction. Effective treatment includes therapy, support groups, and aftercare planning, which together promote long-term recovery.
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How Long Do Opiates Stay in Your System? How Long Do Opiates Stay in Urine, Blood, & Body?
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How Long Do Opiates Stay in Your System? Brief Video Transcript.
Drugs in the opioid class are used to treat pain. Natural opioids, semi-synthetic opioids made from natural opioids, and synthetic opioids created in a lab are all called opioids. A class of medications known as opioids contains opiates, which are organic byproducts of the poppy plant. The main difference is that “opiate” refers to the substances derived from the opium (poppy) plant. At the same time, “opioids” are all substances that interact with opioid receptors, including those created in the lab.
The length of time that opiates remain in your system varies depending on the type of opiate, the dosage, and the frequency of use. Generally, opiates can stay in your system for two to four days. However, heavier and chronic users may have residues in their system for up to seven days.
Opiates can be detected in the blood test for up to 24 hours and in the urine test for up to three days. Opiates can be detected in the hair follicles for up to 90 days. In chronic users, opiates can stay in the body for up to 30 days.
Opiates often have short half-lives, meaning their effects can linger for several hours even though they swiftly leave the body. Opioids can stay in a person’s bloodstream for hours or days after symptoms go away. This depends on the type of substance used. Urine tests are a common way to check for drug use. They can find opioids in the body for three to four days. Some tests can even detect opioid use for up to three months.
Informational Percocet Withdrawal: How Long Opiates Stay in Your System Video
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Search We Level Up Percocet Detox, Mental Health Topics & Resources
Resources
Percocet Addiction Symptoms – Builds the foundation: describes physical and psychological symptoms during withdrawal from Percocet, helping people identify what they may experience.
Yellow Percocet Pictures & Oxycodone‑Acetaminophen Effects – Examines a specific form of Percocet (“yellow” pills), including visuals, dosage, side effects, risks (including counterfeit). Helpful for discussions about dosage, risk, and recognition of the drug.
Oxycodone Drug Facts – Goes into what oxycodone is, its classifications, brand names, and how it’s regulated. Since Percocet contains oxycodone, this supports foundational understanding.
Sources
[1] Controlled Substance Schedules – https://www.deadiversion.usdoj.gov/schedules/ – Drug Enforcement Administration
[2] PAIN MANAGEMENT BEST PRACTICES INTER-AGENCY TASK FORCE REPORT – https://www.hhs.gov/sites/default/files/pmtf-final-report-2019-05-23.pdf – U.S. Department of Health and Human Services (HHS)
[3] MAT Medications, Counseling, and Related Conditions – https://www.samhsa.gov/medication-assisted-treatment/medications-counseling-related-conditions – Substance Abuse and Mental Health Service Administration
[4] Overdose Death Rates – National Institute on Drug Abuse (NIDA)
[5] Understanding Drug Overdoses and Deaths – CDC Injury Center
[6] Now is Not the Time for the CDC to Relax Opioid Prescription Guidelines – Florida Health Across the State
[7] National Opioids Crisis: Help and Resources – HHS.gov
[8] Oxycodone and acetaminophen tablets, USP – Food & Drug Administration (FDA)
[9] Sadiq NM, Dice TJ, Mead T. Oxycodone. [Updated 2022 Aug 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482226/
[10] Van Zee A. The promotion and marketing of oxycontin: commercial triumph, public health tragedy. Am J Public Health. 2009 Feb;99(2):221-7. DOI: 10.2105/AJPH.2007.131714. Epub 2008 Sep 17. PMID: 18799767; PMCID: PMC2622774.


