Skip to content

What is Codeine? Uses, Side Effects & Drug Abuse Information

Codeine is the most commonly taken opioid medication. It is at the center of the opioid addiction problem in the United States and thus is highly regulated. Codeine's main indications are pain and dry cough. Read more about codeine uses, effects, addiction, and rehab treatment.

By We Level Up | Editor Yamilla Francese | Clinically Reviewed By Lauren Barry, LMFT, MCAP, QS, Director of Quality Assurance | Editorial Policy | Research Policy | Last Updated: April 19, 2023

What is Codeine?

Is codeine an opioid? Yes. Codeine is a type of narcotic pain medication that belongs to the medicines known as opioids. It is a natural derivative of opium used primarily to treat mild to moderate pain, coughing, and diarrhea. In the United States, codeine is a controlled substance, and its classification as a drug schedule depends on the specific formulation and the amount of codeine it contains. Codeine is commonly classified as a Schedule II, III, or V drug.

Codeine binds to specific brain and spinal cord receptors, which can help reduce pain and suppress coughing and diarrhea. It is often combined with other pain relievers, such as acetaminophen or ibuprofen, to increase its effectiveness. Codeine is available by prescription and is typically taken orally as tablets, capsules, or syrup. It can be habit-forming and has a high potential for opioid use disorder or opioid addiction, mainly if misused or for extended periods.

Common codeine adverse effects include drowsiness, dizziness, nausea, vomiting, constipation, and difficulty breathing. It is crucial to use codeine only as directed by a healthcare professional and to be aware of the risks associated with its use.

How Long Does Codeine Stay in Your System?

Does codeine show up in a drug test? Yes. For most individuals, codeine can be seen in their urine for up to forty-eight hours after their previous drug use.

Codeine Drug TestDrug Test Codeine Timeline
UrineGenerally, codeine stays present in urine for 1-2 days.
SalivaCodeine can appear in saliva drug tests in as few as 15 minutes. Then, codeine will drop below testable levels in 1-2 days.
BloodCodeine is generally detectable in the blood for only 24 hours.
HairA hair follicle test can see codeine for up to 90 days.
Codeine drugs, like other opioid medications, are included in the typical and most common drug panel.

For chronic codeine users, the drug can be detected through drug panels for up to one week or more.

Codeine Cough Syrup Side Effects

Codeine cough syrup can be an effective cough treatment but can also cause several side effects. Some common side effects of codeine cough syrup include:

  • Drowsiness and Sedation: Codeine can cause drowsiness and sedation, impairing your ability to drive or operate machinery.
  • Dizziness: Cough syrup codeine can cause dizziness or lightheadedness, increasing the risk of falls.
  • Nausea and Vomiting: Codeine can cause stomach upset, nausea, and vomiting.
  • Constipation: Codeine for a cough can cause constipation by slowing bowel movement.
  • Respiratory Depression: Codeine can suppress breathing and can be especially dangerous for people with respiratory problems or taking other medications that can cause respiratory depression.
  • Codeine Allergy Reactions: Some people may experience allergic reactions to codeine for cough, including rash, itching, swelling, and difficulty breathing.
  • Dependence and Codeine Abuse: Codeine has a high potential for dependence and addiction, mainly when used for extended periods or in higher doses than recommended.

Why is Codeine Addictive?

Codeine is addictive because it is an opioid, meaning it can produce euphoria, pleasure, and relaxation when it binds to specific brain and spinal cord receptors. Does codeine get you high? Yes. These pleasurable “high on codeine” effects can lead to psychological dependence, where a person feels compelled to use the drug repeatedly to experience the same impact.

Codeine can also cause physical dependence, where the body adjusts to the presence of the drug and experiences withdrawal symptoms if it is stopped suddenly. Withdrawal symptoms include nausea, vomiting, diarrhea, sweating, chills, insomnia, and body aches.

Furthermore, people may develop codeine addiction by taking higher doses than recommended, taking it more frequently than prescribed, or using it with other drugs or alcohol. Misusing codeine can increase the risk of a substance use disorder, overdose, and other negative consequences.

Codeine is a prescription medication that should only be used as directed by a healthcare professional. Suppose you are concerned about the potential for addiction or misuse. In that case, talking to your healthcare provider about alternative treatments and strategies to manage pain or other symptoms is crucial.

Codeine Lean

“Codeine lean” is a term commonly used to refer to a recreational drug mixture that contains codeine (an opiate) and a carbonated beverage, such as soda or energy drink, along with candy or other sweeteners. Is lean addictive? Yes! This mixture is often consumed in large quantities and can produce a sense of euphoria, relaxation, and drowsiness.

Lean addiction can be very hazardous and even deadly. Codeine is a highly addictive drug and can cause respiratory depression, coma, and death if taken in excessive amounts or mixed with other medicines, especially alcohol. Furthermore, guaifenesin codeine syrup for recreational purposes is illegal in many countries.

What is codeine lean? "Lean" or "purple drank" has become popular in nightclubs and parties. This is because the mixture can produce euphoria, relaxation, and drowsiness, which some people find appealing in social situations.
What is codeine lean? “Lean” or “purple drank” has become popular in nightclubs and parties. This is because the mixture can produce euphoria, relaxation, and drowsiness, which some people find appealing in social situations.

What Does Codeine Look Like?

Codeine is available in different forms and dosages, so its appearance can vary depending on the product. Some common forms of codeine include tablets, capsules, and syrup. Promethazine codeine cough syrup is a liquid medication that is usually brown or purple and has a sweet taste. It may be packaged in a bottle or a small cup.

What is codeine addiction? Codeine is an opioid medication that can produce feelings of euphoria, relaxation, and pain relief. When a person becomes addicted or dependent on codeine, they may experience various symptoms and behaviors.
What is codeine addiction? Codeine is an opioid medication that can produce feelings of euphoria, relaxation, and pain relief. When a person becomes addicted or dependent on codeine, they may experience various symptoms and behaviors.

Learn More:

How addictive is lean? Codeine, the main ingredient in lean, is a highly addictive opiate that can cause physical dependence and withdrawal symptoms when used regularly or in high doses. Promethazine with codeine side effects can also cause drowsiness and other side effects, especially when combined with other drugs or alcohol. Mixing lean with other substances, such as alcohol, benzodiazepines, or other opiates, can increase the risk of respiratory depression, coma, and death.

If you or someone you’re concerned with is addicted to lean, seeking professional help from a healthcare provider or codeine addiction specialist is crucial.

Is Tylenol With Codeine Addictive?

Yes, Tylenol with codeine effects can be addictive due to its codeine content. Codeine is an opioid analgesic, which means it is a type of pain medication that works by binding to the brain’s opioid receptors and spinal cord to reduce pain sensations. Like other opioids, Tylenol codeine effects can cause physical dependence and addiction when used regularly or in high doses. Dependency occurs when the body adjusts to Tylenol and codeine and requires it to function normally. Despite the negative consequences, addiction to codeine Tylenol high is a chronic disease characterized by compulsive drug use.

Taking Tylenol with codeine for a short period and under the direction of a healthcare provider is generally safe. However, prolonged or unsupervised use of Tylenol with codeine can increase the risk of codeine addiction, overdose, and other health complications.

It is crucial to follow the prescribed dosage and not take more than the recommended amount. Suppose you or someone you’re concerned with is struggling with addiction to Tylenol with codeine high or other drugs. In that case, seeking professional help from a healthcare provider or addiction specialist is critical.

Acetaminophen Codeine 3

Acetaminophen codeine 3, also known as Tylenol with codeine 3, is a prescription medication that contains codeine (an opioid pain reliever) and acetaminophen (a non-opioid pain reliever). It is used for the treatment of moderate to severe pain.

Codeine functions by binding to opioid receptors in the brain and spinal cord, which reduces pain signals. On the other hand, acetaminophen works by inhibiting the release of prostaglandins, which are the primary cause of pain and inflammation in the body.

While acetaminophen codeine 3 can be an effective pain management medication when appropriately used, codeine is a highly addictive drug that can cause physical dependence and withdrawal symptoms when used regularly or in high doses. Acetaminophen can also be toxic to the liver if taken excessively or over a prolonged period.

Acetaminophen Codeine Side Effects

  • Some of the common side effects of side effects of tylenol 3 with codeine include the following:
  • Drowsiness.
  • Dizziness.
  • Nausea and vomiting.
  • Constipation.
  • Dry mouth.
  • Blurred vision.
  • Headache.
  • Sweating.
  • Itching or rash.
  • In addition to these common tylenol 3 codeine side effects, acetaminophen codeine 3 can also cause severe side effects in some cases, such as the following:
  • Respiratory depression. (slow breathing)
  • Hypotension. (low blood pressure)
  • Hepatotoxicity. (liver damage)

Codeine Guaifenesin Addiction

Codeine is an opioid pain reliever, and guaifenesin is an expectorant. Codeine guaifenesin 10-100 mg/5ml should only be used as prescribed by a healthcare provider for their intended purpose, which is to relieve cough and congestion caused by respiratory conditions. Using Codeine Guaifenesin recreationally, in more significant amounts or more frequently than prescribed, can lead to physical dependence, addiction, and other serious health consequences. Codeine guaifenesin can also interact with other medications or substances, such as alcohol, increasing the risk of adverse effects and overdose.

Suppose you or someone you’re concerned with is struggling with substance abuse or codeine guaifenesin high addiction. In that case, seeking professional help from a healthcare provider or addiction specialist is crucial. They can provide information on treatment options and support to help overcome codeine addiction.

Codeine vs Hydrocodone

Hydrocodone vs codeine are both prescription opioid pain relievers that are used to treat moderate to severe pain. Codeine is a weaker opioid compared to hydrocodone and is often taken in combination with other medications, such as acetaminophen, to enhance its pain-relieving effects. Hydrocodone, on the other hand, is a more potent opioid pain reliever and is often prescribed for more severe pain relief.

Does hydrocodone have codeine in it? To put it simply, hydrocodone is synthesized by the isomerization of codeine. Most people often call these medications “hydro codeine pills.” Like other opioids, hydrocodone can induce respiratory depression, sedation, mental and physical performance impairment, constipation, and urinary retention. Drug dependence and addiction are possible to occur with long-term use.

What is codeine addiction? When codeine is used for a long period, it may become habit-forming, causing mental or physical dependency. 
What is codeine addiction? When codeine is used for a long period, it may become habit-forming, causing mental or physical dependency. 

Codeine Withdrawal Symptoms

Codeine is an opioid medication that can cause physical dependence and withdrawal symptoms when used regularly or in high doses. Codeine withdrawal symptoms can range from mild to severe and vary depending on individual factors such as the duration and amount of codeine use.

Some common codeine withdrawal symptoms include the following:

  • Anxiety.
  • Restlessness.
  • Irritability.
  • Insomnia.
  • Muscle aches and pains.
  • Nausea and vomiting.
  • Diarrhea.
  • Sweating.
  • Chills.
  • Runny nose and watery eyes.
  • Dilated pupils.
  • Increased heart rate and blood pressure.

Codeine Overdose Symptoms

Can you overdose on codeine? Yes! The same goes for other opioid drugs. Codeine is an opioid medication that can cause an overdose when taken in large amounts or in combination with other drugs or substances, such as alcohol. A codeine overdose can be life-threatening and requires emergency medical attention.

Some common symptoms of codeine overdose include the following:

  • Slow, shallow breathing, or difficulty breathing.
  • Blue or gray skin or lips.
  • Cold, clammy skin.
  • Extreme drowsiness or loss of consciousness.
  • Pinpoint pupils.
  • Weakness or limpness.
  • Low blood pressure.
  • Slow heart rate.
  • Coma.

For both codeine withdrawal and overdose symptoms, it is crucial to seek emergency medical attention. If left untreated, a codeine overdose can lead to brain damage, respiratory failure, or even death. Also, without proper opioid detoxification, a person is subject to relapse to addiction repeatedly, heightening the risk of an overdose.

Naloxone (Narcan) is a medication that can reverse an opioid overdose and save a person’s life. It functions by blocking the effects of opioids on the brain and restoring normal breathing. If you are concerned about opioid overdose or want naloxone, you must talk to your healthcare provider or pharmacist. Many states have standing orders that allow pharmacists to dispense naloxone without a prescription.

Codeine Drug Facts

Generic Name: Codeine [ KOE-deen ]

Drug Classes: Antitussives, Opioids (narcotic analgesics)

Codeine Drug Schedule: In the United States, codeine is a prescription medication classified as a Schedule II controlled drug.

Codeine in Spanish: “Codeina” or “Codeina 3”

Codeine Cough Syrup Brands: Brand names Phenergan with codeine (promethazine and codeine) and Tuzistra (chlorpheniramine and codeine) are some samples of codeine-containing drugs used to ease coughs and cold symptoms, such as sneezing, runny or stuffy nose, and other allergy signs.

Other Drugs With Codeine:

  • Fioricet with codeine is a combination drug product to treat a tension headache.
  • Codeine sulfate is an opioid analgesic for alleviating mild to moderately severe pain where an opioid anesthetic is suitable.
  • Robitussin Ac (codeine-guaifenesin) combines an expectorant and a narcotic to treat cough and reduce chest congestion caused by upper respiratory infections or the common cold. People often call it “Robitussin codeine” or Robitussin with codeine.
  • Acetaminophen and codeine (Tylenol-codeine phosphate) is a combination drug containing codeine and acetaminophen to relieve pain. It is also known as “APAP/codeine” or “APAP codeine” in the medical field.
    • Numerous pharmacists still use this abbreviation when writing patient-specific prescription labels. Patients may need to understand that APAP means acetaminophen.
  • Promethazine with codeine syrup relieves cough, runny or stuffy nose, sneezing, or other symptoms induced by allergies or the common cold. Promethazine is an antihistamine. It prevents the effects of a substance called histamine, produced by the body.

Can You Snort Codeine?

Technically, it is possible to snort codeine, but it is not a recommended method of administration. Codeine is designed to be taken orally as a pill, syrup, or tablet, and snorting it can increase the risk of codeine addiction and overdose. Snorting codeine can irritate the nasal passages, cause nosebleeds, and damage the delicate tissues inside the nose.

Snorting codeine can lead to a more rapid onset of effects and a higher concentration of the drug in the bloodstream, which can increase the risk of overdose and other adverse effects.

How Addictive is Codeine?

Codeine as a drug can be habit-forming. Addiction to codeine leads not only to psychological dependency but also to physical manifestations through unwanted withdrawals.

The Codeine drug class is opioid. Opioid common drugs such as codeine and morphine are highly addictive. Is codeine a drug? Yes. Unfortunately, codeine narcotics are often misused for the euphoria they produce, and they’re prevalent in nightclubs and even among college students.

It is critical to use the drug codeine only as advised by a healthcare provider and to avoid methods of liquid codeine administration that are not recommended or approved. Moreover, it is crucial to store codeine medicine and other medications safely and securely out of reach of children and others who might misuse them.

Following your doctor’s recommended dosage for codeine can save your life. But for someone who may have been addicted to codeine drugs already, seeking professional help from an accredited rehab treatment center can help avoid the dangers of opioid withdrawal and overdose.

Ryan Zofay forming a circle and hugging friends.

Get Your Life Back

Find Hope & Recovery. Get Safe Comfortable Detox, Addiction Rehab & Dual Diagnosis High-Quality Care.

Hotline(844) 597-1011

Codeine Addiction Statistics

Prolonged use of codeine can lead to addiction, tolerance, and dependence, which can have serious health consequences. However, many users find ways to get addicted to the drug recreationally and fast. Lean drink, also known as Purple drank, Sizzurp, or Dirty Sprite, is a recreational drug concoction that originated in Southern hip-hop culture. It generally consists of prescription-strength cough syrup containing promethazine with codeine dosage, mixed with soda (often Sprite) and sometimes candy, such as Jolly Ranchers, and ice.

The codeine in the cough syrup is a powerful opioid pain medication that can cause feelings of euphoria and relaxation. At the same time, promethazine is an antihistamine that can enhance the effects of codeine. The soda and candy are added to improve the taste and mask the bitter flavor of the cough syrup.

However, the lean drink is a dangerous and potentially deadly drug. The combination of codeine and promethazine can cause respiratory depression, leading to coma or death. The high doses of codeine in cough syrup can also lead to addiction, tolerance, and dependence. Lean drinking is illegal and can have serious health consequences. If you or someone you’re concerned with is struggling with codeine addiction, seeking professional help and support is crucial.

In 2018, 1,029 party attendees (ages 18–40) were surveyed in New York City utilizing time-space sampling. Prevalence and correlates of Lean drinking were estimated. This survey is available from the published research in NCBI (National Center for Biotechnology Information). [2]


15.5%

An estimated 15.5% of attendees have used Lean, a codeine-contained drink, and 3.4% have used it in the past year.

Source: NCBI

14.2%

Only an estimated 0.2% have used it in the past month, but 14.2% would use it next month if offered by a friend.

Source: NCBI

75.4%

Three-quarters (75.4%) of users believed Lean contained codeine, and 32.4% thought it always or usually had codeine.

Source: NCBI


Top 10 What Does Codeine Do? FAQs

  1. What is codeine used for?

    Codeine is an opioid prescription medication used to relieve pain and treat cough. It is derived from the opium poppy and functions by binding to the brain’s opioid receptors and spinal cord, lessening the perception of pain and suppressing the cough reflex.

  2. What type of drug is codeine?

    Is codeine a narcotic? Yes, codeine is a narcotic opioid medication. As a drug, codeine has a high potential for opioid use disorder and dependence.

  3. What schedule drug is codeine?

    It is classified as a Schedule II controlled substance in the United States, which means it is subject to strict regulations and monitoring by the DEA (Drug Enforcement Administration.)

  4. What are the effects of codeine?

    The effects of codeine can vary depending on the individual, the dose, and the method of administration. As an opioid medication, codeine works by reducing the perception of pain and suppressing the cough reflex. However, misusing codeine or using it for non-medical purposes can lead to addiction, overdose, and other severe health consequences.

  5. What are the common tylenol with codeine side effects?

    Is Tylenol codeine addictive? Yes, one of the side effects of Tylenol with codeine is addiction. Tylenol with codeine 4 or 3 is an opioid medication that combines codeine and acetaminophen (the active ingredient in Tylenol). As an opioid, codeine has a high potential for abuse and dependence. While Tylenol with codeine can effectively relieve pain and cough, it can also produce feelings of pleasure and well-being, which can be attractive to some individuals but can also lead to addiction and dependence.

  6. Does codeine show up on a drug test?

    Does codeine show up on drug tests? Yes, codeine can show up on drug tests. Codeine is an opioid medication and is one of the drugs that is typically screened for in drug tests that specifically look for opioids.

  7. Is tramadol stronger than codeine?

    Tramadol is generally considered to be stronger than codeine. Tramadol is a synthetic opioid medication that works by binding to the brain’s opioid receptors and spinal cord, lessening the perception of pain.

  8. Does promethazine have codeine in it?

    Does promethazine DM have codeine in it? Promethazine DM is a combination medication containing two active ingredients, promethazine, and dextromethorphan. It does not contain codeine. However, some combination medications contain promethazine and codeine, such as Phenergan with codeine. Always check the label and speak to your doctor or pharmacist if you have any inquiries about the promethazine/codeine ingredients in your medication or how to take it properly.

  9. Does percocet have codeine in it?

    No, Percocet does not contain codeine. Percocet is a combination medication containing oxycodone and acetaminophen active ingredients. Oxycodone is an opioid pain relief drug, while acetaminophen is a non-opioid fever reducer and pain reliever. Codeine is another opioid pain medication sometimes used to treat pain but is not present in Percocet.

  10. How much codeine to get high?

    How much codeine gets you high? Codeine is a powerful opioid medication typically used to treat pain or coughing under the supervision of a doctor. Codein can lead to addiction, overdose, and other serious health risks. It’s illegal to use codeine without a prescription, and doing so can result in legal consequences and adverse health effects. If you’re struggling with opioid use disorder, please seek support from a healthcare professional or addiction specialist.

Get Help. Get Better. Get Your Life Back.

Searching for an Accredited Drug and Alcohol Rehab Centers in Near You?

Even if you have failed previously and relapsed, or are in the middle of a difficult crisis, we stand ready to support you. Our trusted behavioral health specialists will not give up on you. When you feel ready or just want someone to speak to about therapy alternatives to change your life call us. Even if we cannot assist you, we will lead you to wherever you can get support. There is no obligation. Call our hotline today.

(844) 597-1011
What is codeine? The possibility of codeine addiction is high among people who use it recreationally. However, guaifenesin with codeine high can also occur in patients prescribed the drug. Guaifenesin codeine high happens when you take the drug more than the recommended dose. For anyone suffering from codeine addiction, it is crucial to get professional help as opioid addiction can be lethal, and the withdrawal is dangerous without medical guidance.
What is codeine? The possibility of codeine addiction is high among people who use it recreationally. However, guaifenesin with codeine high can also occur in patients prescribed the drug. Guaifenesin codeine high happens when you take the drug more than the recommended dose. For anyone suffering from codeine addiction, it is crucial to get professional help as opioid addiction can be lethal, and the withdrawal is dangerous without medical guidance.

The Effects of Guaifenesin-Codeine

Codeine and guaifenesin are commonly used together to relieve coughs associated with respiratory tract infections or allergies. While these medications are generally safe when used as directed, they can cause side effects in some people. Some of the common codeine guaifenesin side effects include the following:

  • Drowsiness and fatigue.
  • Nausea and vomiting.
  • Constipation or diarrhea.
  • Dizziness or lightheadedness.
  • Headache.
  • Dry mouth.
  • Sweating.
  • Rash or itching.

In rare cases, codeine can cause more severe side effects, such as respiratory depression (slowed breathing) or allergic reactions. If you encounter any of the following symptoms after taking codeine and guaifenesin, seek medical attention right away:

  • Difficulty breathing.
  • Chest pain or tightness.
  • Severe drowsiness or confusion.
  • Seizures.
  • Hallucinations.
  • Fainting or loss of consciousness.

Other Acetaminophen-Codeine Effects

Codeine acetaminophen is often used to relieve pain. While acetaminophen/codeine is generally safe when used as directed, it can cause side effects in some people. Often, many people call it “acetami/codein.” Long-term use of codeine and acetaminophen can also lead to dependence, addiction, or liver damage. It’s crucial always to follow your doctor’s instructions when taking any medication and to report any side effects you experience to your healthcare provider.

In rare cases, codeine and acetaminophen can cause more severe side effects, such as respiratory depression (slowed breathing) or allergic reactions. If you undergo any of the following symptoms after taking codeine and acetaminophen, seek medical attention right away:

  • Chest discomfort or tightness.
  • Problem breathing.
  • Severe tiredness.
  • Loss of consciousness.
  • Seizures.
  • Hallucinations.

Acetaminophen / Codeine Side Effects

Some of the common side effects of codeine and acetaminophen (acetaminophen codeine 3 efectos secundarios) include the following:

  • Dizziness or sleepiness.
  • Nausea.
  • Stomach discomfort and constipation.
  • Dry mouth.
  • Headache.
  • Sweating.
  • Allergic codeine reactions, such as rashes.

Side Effects of Tylenol Codeine

Tylenol with codeine #3 is a prescription medication containing codeine and acetaminophen. This medication relieves mild-to-moderate pain, such as pain from dental work, surgery, or injury. While Tylenol with codeine #3 is generally safe when used as directed, it can cause side effects in some people. One common side effect of Tylenol with codeine #3 is drowsiness. Other Tylenol with codeine 3 side effects are the same as the side effects of codeine acetaminophen and guaifenesin codeine medicines.

In rare cases, Tylenol with codeine #3 can cause more severe side effects, such as respiratory depression (slowed breathing) or allergy to codeine. Long-term use of Tylenol with codeine #3 can also lead to dependence, addiction, or liver damage. It’s crucial always to follow your doctor’s instructions when taking any medication and to report any side effects you experience to your healthcare provider.

Codeine Promethazine Side Effects

Codeine and promethazine can cause more severe side effects, such as respiratory depression (slowed breathing), allergic reactions, or drowsiness. If you experience any of the symptoms after taking codeine and promethazine, seek medical attention right away. Codeine and promethazine are commonly used together to relieve coughs associated with respiratory tract infections or allergies. The effects of codeine and promethazine can include the following:

  • Relief of cough: Codeine is a cough suppressant that blocks the brain’s cough reflex. Promethazine is an antihistamine that can also help relieve cough by reducing inflammation in the airways.
  • Pain relief: Codeine is also a mild pain reliever that can help relieve mild-to-moderate pain.
  • Sedation: Both codeine and promethazine can cause drowsiness and sedation, which can help promote restful sleep when used at night.
  • Relaxation of muscles: Codeine and promethazine can also cause relaxation of the muscles, which can help relieve muscle spasms or tension.
What is codeine used for? Codeine is a prescription medication that relieves mild-to-moderate pain, cough, and diarrhea. Codeine is a controlled substance and can be habit-forming if used inappropriately.
What is codeine used for? Codeine is a prescription medication that relieves mild-to-moderate pain, cough, and diarrhea. Codeine is a controlled substance and can be habit-forming if used inappropriately.

The side effects of promethazine with codeine can occur to anyone, so it’s best to follow your doctor’s instructions. These medications should only be used as directed by your healthcare provider and should not be taken in more significant amounts or longer than prescribed. If you experience any codeine / promethazine side effects or have concerns about using codeine and promethazine, speak with a healthcare professional.

First-class Facilities & Amenities

World-class High-Quality Addiction & Mental Health Rehabilitation Treatment

Rehab Centers Tour

Renowned Addiction Centers. Serene Private Facilities. Inpatient rehab programs vary.

Addiction Helpline(844) 597-1011

Proven recovery success experience, backed by a Team w/ History of:

  • 15+ Years Experience
  • 100s of 5-Star Reviews
  • 10K+ Recovery Successes
  • Low Patient to Therapist Ratio
  • Onsite Medical Detox Center
  • Comprehensive Dual-Diagnosis Treatment
  • Complimentary Family & Alumni Programs
  • Coaching, Recovery & Personal Development Events

What are the Side Effects of Codeine?

Constipation is one of the most common adverse effects of codeine. Most patients report some stomach discomfort and constipation following the start of codeine pharmacotherapy or increases in dose. With persistent exposure, the resolution of stomach discomfort and constipation does not occur. The clinician should recommend stool softeners along with a codeine prescription. Nausea or vomiting is another common unfavorable effect expected to subside within days to weeks of continued codeine exposure. Anti-emetic treatments in oral and rectal formulations are available to treat vomiting and nausea.

Clouded mentation or sedation following codeine treatment initiation tends to fade over time. Yet, during initiation or increasing doses, patients should acquire counseling about considering precautions at work and restrictions with driving. They should also comprehend the effects and risks of simultaneous exposure to other substances and drugs with sedating effects.

What are side effects of codeine? Other common adverse effects include the following:

  • Pruritis – Pruritus, commonly called itching, is an unpleasant sensation that causes the desire to scratch or rub the affected area.
  • Urinary Retention – Urinary retention is when a person has difficulty or cannot empty their bladder.
  • Hypersensitivity – An allergic reaction is an abnormal immune response to a normally harmless substance.
  • Bronchospasm – A condition in which the muscles around the airways in the lungs contract and narrow, making breathing difficult.
  • Tremor, blurred vision, weakness, abdominal cramps, and pancreatitis.

Clinicians must assess opioid rotation when patients chronically on a particular opioid experience intolerable adverse effects or poor relief despite dose increments. Individuals with sleep apnea or other coexisting pulmonary diseases may be at a higher risk for respiratory depression, and doses must be started and titrated cautiously.

What is codeine side effects on pregnancy? Adverse newborn outcomes such as premature birth, low birth weight, hypoxic-ischemic brain injury, and neonatal death may occur when used in pregnancy. Newborns may also have neonatal abstinence syndrome.

Short Term Effects of Codeine

Codeine is an opioid pain medication often prescribed for short-term use to manage pain. Codeine short term effects include the following:

  • Pain relief: Codeine works by binding to the spinal cord, opioid receptors in the brain, and other parts of the body, which can help to reduce pain.
  • Sedation effects on codeine: Codeine can cause drowsiness and sedation, which can help manage pain and promote rest.
  • Cough suppression: Codeine is sometimes used in cough syrup to help suppress coughing.
  • Constipation: Codeine can slow down the movement of the digestive tract, leading to constipation.
  • Nausea and vomiting: Codeine can cause nausea and vomiting, especially when taken in higher doses or for more extended periods.
  • Euphoria: Like other opioids, codeine can cause euphoria or a “high” when taken in higher doses than prescribed.
  • Respiratory depression: In high dosages or combined with other prescription drugs that depress the central nervous system, codeine can cause respiratory depression, a potentially life-threatening condition.

Long Term Effects of Codeine

Long term codeine effects, especially at high doses or in combination with other drugs, can lead to several potential adverse effects, including the following:

  • Tolerance: Over time, the body may become accustomed to the effects of codeine, leading to the need for higher doses to achieve the same level of pain relief.
  • Dependence: With prolonged use, the body may develop a physical dependence on codeine, leading to withdrawal symptoms when use is stopped.
  • Addiction: Codeine long term effects can increase the risk of developing addiction or substance use disorder, especially in individuals with a history of substance use disorders or mental health conditions.
  • Respiratory problems: Long-term use of codeine can lead to respiratory problems, including breathing difficulties, chronic cough, and even respiratory failure.
  • Liver damage: Chronic use of codeine can lead to liver damage, especially when combined with other drugs or alcohol.
  • Hormonal problems: Long-term use of codeine can lead to hormonal imbalances, including reduced testosterone levels in men and menstrual irregularities in women.
  • Cognitive impairment: Prolonged use of codeine can lead to cognitive impairment, including memory problems, slowed thinking, and difficulty concentrating.

What is the side effects of codeine on sex? Evidence suggests that long-term use of opioids like codeine can lead to sexual dysfunction, including decreased libido, erectile dysfunction, and delayed or absent orgasm. This is thought to be related to the way opioids affect the brain and the body’s natural production of hormones that are important for sexual function.

However, sexual dysfunction is not a common side effect of short-term use of codeine or other opioids. If you are experiencing sexual dysfunction and are taking codeine or another opioid, it’s critical to talk to your healthcare provider. They may be able to modify your medication plan or recommend other treatments to help alleviate your codeine sexual dysfunction symptoms. Furthermore, sexual dysfunction can have many causes, such as anxiety, depression, or other health conditions. Hence, a thorough evaluation by a healthcare provider is essential to determine the underlying cause and the best course of treatment.

What is codeine addiction treatment? When dealing with the risks of codeine and addiction problems, the care and supervision of a medical professional accredited for opioid addiction treatment are necessary.
What is codeine addiction treatment? When dealing with the risks of codeine and addiction problems, the care and supervision of a medical professional accredited for opioid addiction treatment are necessary.

Codeine Phosphate Addiction

Codeine phosphate is a powerful opioid pain medication that can be addictive when used over a long period or in high doses. The risk of codeine addiction is incredibly high when codeine is used in a way that is not prescribed by a healthcare provider, such as taking larger doses than recommended or using it for non-medical purposes.

Codeine is known to bind to opioid receptors in the brain and other parts of our body, which can lead to euphoria, relaxation, and pain relief. Over time, the body may become tolerant to the effects of codeine, requiring higher doses to achieve the same level of pain relief or to experience the desired results. This can lead to physical dependency and unwanted withdrawal symptoms when use is stopped.

The signs of codeine addiction are:

  • Using codeine in more significant amounts or for more extended periods than prescribed.
  • Craving codeine and feeling unable to control the use.
  • Continuing to use codeine despite negative consequences, such as financial or relationship problems.
  • Spending a lot of time thinking about codeine or seeking it out.
  • Using codeine to cope with emotional issues or stress.
  • Withdrawal symptoms include anxiety, agitation, sweating, and gastrointestinal problems when use is stopped.

Prescription drug addiction, such as codeine addiction, can be challenging to recognize. Codeine addiction often develops gradually and can be hidden from others. However, there are some general signs and symptoms that may indicate a prescription drug addiction, including the following:

  • Using more medication than prescribed or using it for longer than intended.
  • Continue using the medicine even after the original condition or injury has resolved.
  • Needing the drug to feel “normal” or function in daily life.
  • Experiencing withdrawal symptoms when attempting to stop or reduce medication use.
  • Continue using the medicines despite experiencing negative consequences, such as relationship problems, financial difficulties, or legal issues.
  • Spending significant time and effort obtaining the drug, such as doctor shopping or stealing from others.
  • Hiding or lying about medication use.
  • Neglecting essential responsibilities, such as work, school, or family obligations, to use the medication.
  • Using the medicine recreationally, such as crushing and snorting pills or injecting them.
  • Experiencing mood, behavior, or personality changes, such as irritability, aggression, or depression.

Codeine Addiction Treatment

If you think you or someone you’re concerned with has codeine addiction, seeking professional help is crucial. Treatment options for codeine addiction may include behavioral therapy programs like cognitive-behavioral therapy and medication-assisted treatment. These programs can help to manage withdrawal symptoms and reduce the risk of relapse.

Medication-assisted treatment (MAT) is a good treatment option for people with codeine addiction. MAT combines medication, such as buprenorphine or methadone, with behavioral therapy and counseling to address codeine addiction’s physical and psychological aspects. Buprenorphine medication is a partial opioid agonist that can aid in reducing cravings and withdrawal symptoms linked with codeine addiction. It binds to the same opioid receptors as codeine but with less euphoria and sedation. Methadone is a full opioid agonist that also works by binding to opioid receptors, but it is typically used for more severe cases of codeine addiction.

Along with medication, counseling can help address the underlying psychological factors contributing to codeine addiction. Cognitive-behavioral therapy (CBT) and contingency management (CM) are two standard behavioral therapies used in MAT. CBT helps people comprehend and change negative thought patterns and behaviors that contribute to codeine addiction, while CM rewards positive behaviors, such as staying drug-free. MAT may also be provided in a residential or inpatient setting. Working with a healthcare provider specializing in codeine addiction treatment is crucial to determine the most appropriate treatment plan.

MAT is highly effective in reducing opioid use and helps to improve the overall quality of life for individuals struggling with codeine addiction. However, it is crucial to remember that MAT is just one component of addiction treatment and that individualized, comprehensive care is essential for long-term recovery.

Detoxing from codeine addiction can be challenging, and it’s essential to seek professional help to ensure a safe and successful detox. Here are some general ways that may be involved in a codeine detox:

  • Consult with a medical professional: The first step in any detox process should be to consult a medical addiction professional, such as a doctor or addiction specialist. They can help you create a plan tailored to your needs and monitor your progress.
  • Gradual tapering: If you’ve been using codeine regularly for an extended period, abruptly stopping can lead to withdrawal symptoms. To minimize the discomfort of withdrawal, a gradual tapering schedule may be recommended, where the dosage is gradually reduced over time.
  • Medications to manage withdrawal symptoms: Your healthcare provider may prescribe medications to help manage withdrawal symptoms, such as anxiety, insomnia, and muscle aches. These may include clonidine, benzodiazepines, or antidepressants.
  • Behavioral therapy: Behavioral therapy can help address the underlying psychological and emotional factors that may have contributed to your codeine use. This may include individual therapy, group therapy, or support groups like Narcotics Anonymous.
  • Self-care: During the detox process, it’s crucial to prioritize first self-care practices such as getting enough sleep, creating a healthy diet, and engaging in exercise or other activities that promote overall well-being.
What is codeine addiction treatment? It is essential to seek professional help when trying to quit codeine addiction, as medical supervision can help manage the withdrawal symptoms of codeine and reduce the risk of relapse.
What is codeine addiction treatment? It is essential to seek professional help when trying to quit codeine addiction, as medical supervision can help manage the withdrawal symptoms of codeine and reduce the risk of relapse.

Get FREE codeine addiction treatment insurance check – https://welevelup.com/rehab-insurance/ If you or a loved one is struggling with codeine addiction or other substance use disorder(s), call for a FREE consultation 24/7 at (561) 678-0917.

Top 10 How Long Does Codeine Last In Your System? FAQs

  1. How long does tylenol with codeine stay in your system?

    Does codeine show up in drug tests? Yes. The time that Tylenol with codeine (or acetaminophen with codeine) stays in your system can depend on several factors, including the dosage, how long you’ve been taking it, and individual characteristics such as your metabolism and overall health. However, as a general guideline, codeine has a half-life of approximately 3-4 hours, meaning it takes around 3-4 hours for the body to eliminate half of the drug. Therefore, it can take about 1-2 days for codeine to be eliminated from the body. Acetaminophen has a half-life of around 2-4 hours, and it can take approximately 24 hours to be eliminated from the body.

    If you have been using Tylenol with codeine for an extended period or at high doses, it may take longer for the drug to be eliminated from your system. Furthermore, drug tests can detect the presence of codeine and acetaminophen in your system for up to several days after use. It’s always best to consult a medical professional about how long Tylenol with codeine may stay in your system based on your situation.

  2. Does codeine make you high?

    Yes, codeine addiction can cause a feeling of euphoria or “high” in some people, particularly when taken in larger doses than prescribed or for non-medical purposes. Codeine is an opioid drug that can affect the central nervous system, and it functions by binding to particular receptors in the brain and spinal cord to decrease pain and increase pleasure. However, the euphoric effects of codeine can be hazardous and potentially addictive. In addition to the risk of codeine addiction, taking high doses of codeine can also cause a range of other side effects, including drowsiness, confusion, respiratory depression, and even overdose. If you are prescribed codeine for pain relief, it’s critical to take it only as directed by your healthcare provider and to avoid using it for non-medical purposes. Suppose you are concerned about the potential for codeine addiction or misuse or experiencing side effects from codeine use. Speaking with a medical professional for advice and support is critical.

  3. Can codeine get you high?

    While codeine is primarily used for pain relief, it can cause a feeling of euphoria or “high” in some people when taken in larger doses than prescribed or for non-medical purposes.

  4. What is a “codein drug?”

    Mostly misspelled terms “codein side effects” and “codein addiction” are used to describe codeine addiction. Codeine addiction can be harmful and potentially life-threatening, leading to respiratory depression, overdose, and other health problems. Treatment for codeine addiction may involve detoxification, behavioral therapy, and medication-assisted treatment, which can help manage withdrawal symptoms and cravings and support long-term recovery.

  5. How much codeine does it take to overdose?

    The amount of codeine that can cause an overdose varies depending on several factors, including a person’s age, weight, tolerance, and overall health. Furthermore, the method of administration, such as taking codeine orally or injecting it intravenously, can affect the amount needed to cause an overdose. Signs of a codeine overdose may include respiratory depression, extreme drowsiness, confusion, low blood pressure, weak pulse, and coma. If you suspect someone has overdosed on codeine, it’s necessary to seek immediate medical attention by calling your local emergency services or poison control center.

  6. What are the side effects of codeine cough medicine?

    Cough syrup with codeine side effects are severe; if you experience concerning side effects, such as difficulty breathing or severe dizziness, seek medical attention immediately.

  7. What is the tylenol 3 with codeine side effects?

    Taking too much acetaminophen can be dangerous, and Tylenol codeine 3 side effects can potentially cause liver damage. It’s crucial to take Tylenol with codeine #3 only as advised by your healthcare provider and to prevent taking more than the recommended dosage or using it for non-medical purposes.

  8. What are the guaifenesin codeine side effects?

    Some people may be allergic to codeine or guaifenesin, which can cause side effects of guaifenesin with codeine symptoms such as itching, hives, and difficulty breathing. Moreover, taking too much codeine can be hazardous and potentially cause respiratory depression, leading to difficulty breathing or even respiratory failure.

  9. What are the short-term codeine cough medicine side effects?

    Cough medicine with codeine side effects can cause shallow breathing, difficulty or loud breathing, confusion, more than usual drowsiness, trouble breastfeeding, or limpness in breastfed infants.

  10. What is the common acetaminophen with codeine side effects?

    The side effect of acetaminophen with codeine includes nausea, vomiting, constipation, lightheadedness, dizziness, or drowsiness. Some of these side effects may diminish after using this medication. Advise your doctor or pharmacist promptly if these effects persist or worsen.

How Long Do Opiates Stay in Your System? How Long Do Opiates Stay in Urine, Blood, & Body?

Codeine is an opioid. It is a narcotic medication commonly used for mild to moderate pain treatment, coughing, and diarrhea. Codeine binds to specific brain and spinal cord receptors, which can help reduce pain and suppress coughing and diarrhea. Like other opioids, codeine can be addictive and cause side effects such as drowsiness, constipation, and respiratory depression. It is vital to use codeine only as directed by a healthcare professional and to be aware of the risks associated with its use. The length of opioids stay in your system can vary based on several aspects, including the type of opioid, the dose taken, and individual factors such as age, weight, and metabolism.

One key difference between opiates and opioids is that opiates are all-natural compounds from the opium poppy plant. In contrast, opioids include natural and synthetic compounds that can be manufactured in a laboratory. Another critical difference is that opioids are generally considered to be more potent than opiates, meaning that they can have more substantial and long-lasting effects on the body.

Watch the video below for more information about how long opiates stay in your system.

How Long Do Opiates Stay in Your System? Video Transcript

Welcome to the We Level Up treatment center video series. In today’s video, we will discuss How Long Do Opiates Stay in Your System? How Long Do Opiates Stay in Urine, Blood, & Body? Learn the Hydrocodone, Oxycodone, & Codeine Drug Testing Facts.

The length of time that opiates remain in your system varies depending on the type of opiate, the dosage, and the frequency of use. Generally, opiates can stay in your system for two to four days. However, heavier and chronic users may have residues for up to seven days.

Opiates can be detected in the blood test for up to 24 hours and in the urine test for up to three days. Opiates can be detected in the hair follicles for up to 90 days. In chronic users, opiates can stay in the body for up to 30 days.

Opiates often have short half-lives, meaning their effects can linger for several hours even though they swiftly leave the body. However, Opioids can linger in a person’s bloodstream for several hours or days after the symptoms subside, depending on the substance used. Urine tests, one of the more common types of drug testing, can identify opioid usage for longer periods of time, often up to three to four days, and some tests can identify opioid use for up to three months.

Drugs in the opioid class are used to treat pain. Natural opioids, semi-synthetic opioids generated from natural opioids, and synthetic opioids produced in a lab are all referred to as opioids under the general term. A class of medications known as opioids contains opiates, which are organic byproducts of the poppy plant.

The main difference is that “opiate” refers to the substances derived from the opium (poppy) plant. At the same time, “opioids” are all substances that interact with opioid receptors, including those created in the lab.

What are Opioids?

Opioids, sometimes called narcotics, are medications doctors prescribe to treat persistent or severe pain. They are used by those with persistent headaches and blood alcohol levels, those recovering from surgery or dealing with excruciating pain from cancer, as well as by adults and kids who have suffered major injuries while playing sports or in falls, car accidents, or other situations.

A large class of painkillers known as opioids interact with opioid receptors in your cells to relieve pain. Opioids can be produced in a lab, such as fentanyl, or from the poppy plant. Such as morphine, Kadian, Ms. Contin, Actiq, Duragesic, etc.

Your brain cells release signals that reduce your sense of pain and increase your emotions of pleasure when opioid drugs pass through your blood and bind to opioid receptors. Opioid addiction can happen after just a week of use. The risk for long-term opioid abuse increases after only five days of taking medicine. Some individuals who only intended to use opioids for a week have continued to do so a year later.

Compared to 2019, the age-adjusted rate of drug overdose deaths rose 31% in 2020. Young individuals aged 15 to 24 saw the biggest percentage increase in fatalities, while adults aged 35 to 44 had the greatest rates of drug overdose deaths. The fight against substance use disorders and the opioid pandemic must continue in all facets.

Opiates Drugs Names

There are a variety of opiate drugs, all with different names. Some examples include codeine, morphine, oxycodone, hydrocodone, fentanyl, and methadone. It is important to know the names of opiates when seeking help for addiction, as intervention strategies and treatment plans may depend on the specific opiates being abused.

The top three opiate drugs most commonly prescribed are Hydrocodone, Oxycodone, and Codeine. Other opiate drugs may also be prescribed, depending on your needs and doctor’s advice.

Sources

[1] Peechakara BV, Tharp JG, Gupta M. Codeine. [Updated 2023 Feb 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526029/

[2] What is Codeine? and Codeine Addiction – Available from Palamar JJ. Use of “Lean” Among Electronic Dance Music Party Attendees. Am J Addict. 2019 Sep;28(5):347-352. DOI: 10.1111/ajad.12897. Epub 2019 Apr 30. PMID: 31041819; PMCID: PMC6706295.

[3] Singh AK. Alcohol Interaction with Cocaine, Methamphetamine, Opioids, Nicotine, Cannabis, and γ-Hydroxybutyric Acid, Codeine Addiction. Biomedicines. 2019 Mar 7;7(1):16. DOI: 10.3390/biomedicines7010016. PMID: 30866524; PMCID: PMC6466217.

[4] Learn More About Substance Abuse and Codeine Addiction Treatment – Wackernah RC, Minnick MJ, Clapp P. Alcohol use disorder: pathophysiology, effects, and pharmacologic options for treatment. Subst Abuse Rehabil. 2014 Jan 23;5:1-12. doi: 10.2147/SAR.S37907. PMID: 24648792; PMCID: PMC3931699.

[5] What is Codeine? Learn more About Codeine Addiction. Bhandari M, Bhandari A, Bhandari A. Recent updates on codeine. Pharm Methods. 2011 Jan;2(1):3-8. DOI: 10.4103/2229-4708.81082. PMID: 23781422; PMCID: PMC3658028.

[6] Sproule BA, Busto UE, Somer G, Romach MK, Sellers EM. Characteristics of dependent and non-dependent regular users of codeine. J Clin Psychopharmacol. 1999 Aug;19(4):367-72. DOI: 10.1097/00004714-199908000-00014. PMID: 10440466. What is Codeine? Learn more About Codeine Addiction.

[7] Use of Codeine, Oxycodone, and Other Opioids – Equal Employment Opportunity Commission (.gov)

[8] Timeline of Selected FDA Activities and Significant Events Addressing Substance Use and Overdose Prevention – Food & Drug Administration (FDA) Learn More About Codeine Addiction.

[9] Prevent Opioid Abuse and Addiction – Available from: https://www.hhs.gov/opioids/prevention/index.html

[10] Palamar JJ. Use of “Lean” Among Electronic Dance Music Party Attendees. Am J Addict. 2019 Sep;28(5):347-352. DOI: 10.1111/ajad.12897. Epub 2019 Apr 30. PMID: 31041819; PMCID: PMC6706295.

Table of Contents