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Alcohol and LSD

Interaction, Effects, Health Risks, Indications of Polysubstance Abuse & Best Treatment Options

Can You Mix LSD and Alcohol?

LSD (lysergic acid diethylamide) is a synthetic (man-made) drug that has been abused for its hallucinogenic properties since the 1960s. If consumed in a sufficiently large dose, LSD produces delusions and visual hallucinations that distort the user’s sense of time and identity. It is often called “acid”, an illicit hallucinogenic drug that affects your perceptions for several hours and is detectable on drug addiction screening tests.

LSD (D-lysergic acid diethylamide) is one of the most powerful mind-altering chemicals. It is a clear or white odorless material made from lysergic acid, which is found in a fungus that grows on rye and other grains. [1] Is LSD addictive? LSD is not considered an addictive drug because it doesn’t cause uncontrollable drug-seeking behavior. However, LSD does produce tolerance, so some users who take the drug repeatedly must take higher doses to achieve the same effect. This is an extremely dangerous practice, given the unpredictability of the drug. In addition, LSD produces tolerance to other hallucinogens, including psilocybin.

As the effects of LSD are unpredictable, combining alcohol and LSD is dangerous for you and for your loved one. Adding alcohol into the equation can make a possible bad trip worse and potentially make you aggressive, hostile, or even violent.

Alcohol and LSD
Intentional polysubstance use occurs when a person takes a drug to increase or decrease the effects of a different drug.

LSD and Alcohol Addiction

The effects of taking LSD with other drugs (including those purchased over the counter or prescribed by your doctor) can be unpredictable and dangerous. Using LSD with other substances of abuse increases the chance of a bad trip and can lead to a stroke. Drinking alcohol and LSD may increase the chance of nausea and vomiting.

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LSD and Alcohol Effects

According to Healthline, when you combine alcohol and LSD, it reduces the effects of both substances. [2] This may sound like a good thing if you’re looking to chill out or come down from an especially bad trip, but it’s not that simple. When you mix drugs like alcohol and LSD, you increase the risk of overdose and death. Alcohol consumption further increases the unpredictability of LSD and worsens its adverse effects such as:

  • Hallucinations
  • Distorted visual perception of shapes, colors, movements, touch, and sound (such as “hearing colors” or “seeing sounds”)
  • Altered sounds
  • Feelings of obtaining true insight
  • Distortion of time
  • Anxiety and depression
  • Rapid heart rate
  • Increased body temperature
  • High blood pressure
  • Dilated pupils
  • Profuse sweating
  • Loss of appetite
  • Sleeplessness
  • Dry mouth
  • Tremors

Can You Mix Alcohol and LSD? What are the Risks?

All substances come with risks — and alcohol and LSD are no different. As with any polydrug use, the health risks of using both alcohol and LSD depend on factors such as:

  • How much of each do you ingest
  • Whether or not you’ve eaten
  • Your body size and composition
  • Any other medications you may be taking
  • Preexisting physical and mental health conditions
  • Your tolerance to either LSD or alcohol
  • Your surroundings
Alcohol and LSD
The effects of combining alcohol and LSD may be stronger and more unpredictable than one drug alone, and even deadly.

Users of both hallucinogens and depressants such as alcohol and LSD also risk serious harm because of the profound alteration of perception and mood these drugs can cause.

  • Users might do things they would never do in real life, like jump out of a window or off a roof, for instance, or they may experience profound suicidal feelings and act on them
  • With all drugs, there is also a risk of accidental poisoning from contaminants or other substances mixed with the drug

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What is Polysubstance Abuse

The use of alcohol and LSD, or the use of more than one drug, also known as polysubstance use, is common. This includes when two or more are taken together or within a short time period, either intentionally or unintentionally. According to the Centers for Disease Control and Prevention, 250+ American lives are lost to drugs every day and in 2019, nearly half of drug overdose deaths involved multiple drugs. [3]

Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative affect, and motivation to maintain drug consumption. SUDs are highly prevalent, with 35 million people meeting the criteria for SUD. 

11.3% of individuals diagnosed with a SUD have concurrent alcohol and illicit drug use disorders. Furthermore, having a SUD with one substance increases susceptibility to developing dependence on additional substances. For example, the increased risk of developing heroin dependence is twofold for alcohol misusers, threefold for cannabis users, 15-fold for cocaine users, and 40-fold for prescription misusers. Given the prevalence and risk associated with polysubstance use and current public health crises, examining these disorders through the lens of co-use is essential for translatability and improved treatment efficacy. [4]

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Detox Program

Withdrawal from alcohol and LSD is an important first step to overcoming your addiction. However, withdrawal isn’t an effective treatment by itself. You’ll need further treatment and support to help you in the long term.  [5]

Often, alcohol and LSD can lead to severe withdrawal symptoms. However, proper care and medical supervision will greatly reduce the chances of developing these symptoms and ensure a safe alcohol detox process.

Alcohol and LSD
It may be hard to tell whether a person is high or experiencing an overdose. If you aren’t sure, treat it as an overdose—you could save a life.

Once fully admitted and evaluated, the 2nd stage of detox gets underway:  stabilization.  Based on the data provided during the admissions process, patient feedback, and the symptoms observed;  our experienced team of medical addiction professionals will provide care to keep the patient stable and as comfortable as possible. [6]

Cognitive Behavioral Therapy

Cognitive-behavioral therapy (CBT) is a widely used treatment for alcohol abuse and addiction to help individuals identify negative thought patterns, emotions, and problematic behaviors and learn how to make healthy lifestyle changes that decrease the urges to drink alcohol and use other substances; paying particular attention to symptoms of psychosis, depression, and other co-existing mental health-related problems or dual diagnosis that are exacerbated by stress.

Counseling Services

Individual, group and family counseling services are offered in the majority of mental health and substance abuse treatment programs to “get to the root of the problems”, improve communications and relationships, and motivate the abuser toward positive changes. . The structured guidance of a counselor helps the patient stay on track and in the right perspectives as they strive to achieve their potentials and goals of recovery.

Our FREE 24-hour Hotline can help you with the resources for alcohol and LSD addiction treatment. Get a free consultation now for your best-fitting treatment programs along with free rehab insurance verification. Call We Level Up today and speak with one of our addiction specialists to check your rehab insurance coverage and benefits.

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[1] Hallucinogens DrugFacts – National Institute on Drug Abuse
[2] Is It Safe to Mix LSD and Alcohol? –
[3] Polysubstance Use Facts – Centers for Disease Control and Prevention
[4] One Is Not Enough: Understanding and Modeling Polysubstance Use – National Center for Biotechnology Information
[5] Alcohol Misuse –
[6] Stabilization Treatment Program – We Level Up New Jersey

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