Lunesta Detox Timeline, Withdrawal Symptoms, & Treatment
The duration of Lunesta detox and rehabilitation programs are determined by the individual circumstances and the severity of the addiction. It's crucial to work with a healthcare professional to get the most appropriate course of treatment and to ensure that you have the support and resources you need to successfully overcome your dependency to Lunesta. Read more about Lunesta detox symptoms, timeline, and the best treatment options.
Clinically Reviewed by Lauren Barry, LMFT, MCAP, QS
Medically Reviewed by Ali Nikbakht, PsyD
Reviewed / Updated: September 23, 2025 — Editorial Policy | Research Policy | Privacy Policy
By We Level Up | Editor Yamilla Francese | Clinically Reviewed By Lauren Barry, LMFT, MCAP, QS, Director of Quality Assurance | Editorial Policy | Research Policy | Last Updated: September 23, 2025
What is Lunesta Detox?
Lunesta detox refers to the medically supervised process of discontinuing Lunesta (eszopiclone), a prescription medication used to treat insomnia. Using Lunesta for a long time or incorrectly can cause physical dependence. Stopping the medication suddenly may lead to withdrawal symptoms. These symptoms can include anxiety, trouble sleeping, or mood changes. A structured detox program helps patients slowly reduce their use of Lunesta. Healthcare professionals check for symptoms, offer support, and meet both physical and mental needs. The main goal of Lunesta detox is to make withdrawal safe. It also helps promote long-term recovery and healthy sleep.
Lunesta Detox Overview
Many people worldwide use Lunesta to help with insomnia and other sleep-related issues. However, it is possible to become addicted to this medication accidentally. People frequently misuse and abuse Lunesta with alcohol and opioid drugs, increasing the risk of dependence and overdose. Someone suffering from addiction likely understands that continued drug use has numerous consequences; however, the person continues to use it anyway. After becoming addicted, users may experience severe Lunesta withdrawal symptoms. And the only natural way to treat this issue is through a Lunesta detox.
Lunesta Withdrawal Timeline
The timeline for Lunesta withdrawal can differ for each person. Some may have stronger symptoms that last longer. Suppose you are planning to withdraw from Lunesta. In that case, it is important to work closely with your doctor. Together, you can create a tapering plan. This plan will help reduce your symptoms and avoid any problems.
| Day 1-3 | Within a few days of stopping Lunesta, you might have rebound insomnia. This means the sleep problems you had before may come back. You may also experience anxiety, irritability, and agitation. |
| Day 4-7 | As you withdraw from Lunesta, you may experience more severe symptoms, including tremors, sweating, and headaches. You may also experience gastrointestinal distress, including nausea, vomiting, and diarrhea. |
| Days 8-14 | By the second week of withdrawal, your symptoms may improve, although you may still experience some residual symptoms. You may still have trouble sleeping and feel fatigued during the day. You may also continue to experience mood swings, including anxiety and depression. |
| Days 15-30 | Most of your symptoms should have subsided by the end of the first month of withdrawal. You may still experience lingering effects, including mild insomnia and mood swings. |
Lunesta Withdrawal Symptoms
If you use Lunesta for an extended period and suddenly stop, you will likely experience uncomfortable withdrawal symptoms. Lunesta withdrawal may manifest through the following:
- In more extreme cases, those who quit Lunesta may experience anxiety attacks and seizures.
- One symptom of Lunesta withdrawal is fatigue. This may happen because increased anxiety can affect your sleep. As a result, you may feel tired during the day. Focus on fatigue because it can significantly impact your career and quality of life, making it worth addressing immediately.
- Some users feel a constant low-level anxiety during the day. This anxiety may continue at night and make it hard to sleep.
- Nausea is one of the most annoying symptoms of withdrawal from Lunesta. This is not a mild sickness caused by simple things like seasonal allergies. Instead, withdrawal can lead to effects such as frequent vomiting.
- You may experience memory issues from Lunesta withdrawal, making you seem absent-minded and forgetful. Some people have said they have long periods of activity without remembering what happened. This can include eating a meal.
- One of the more shocking Lunesta withdrawal side effects is mood swings, which may be both violent and sudden. Using and stopping Lunesta affects GABA receptors in your brain. This can lead to mood swings and other mental problems.
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Lunesta Drug Facts
Generic Name: Eszopiclone ( e-ZOP-i-klone )
Drug Class: Sedatives, miscellaneous anxiolytics, and hypnotics
Understanding Lunesta Addiction
Unlike other sleep-aid medications, such as benzodiazepines, Lunesta contains zopiclone, a hypnotic agent. The DEA (Drug Enforcement Administration) classifies Lunesta as a Schedule IV drug. This is because it can be abused and lead to addiction.
The following terms are street names or slang for Lunesta:
- R2.
- Roche.
- Forget-Me Pill.
- Mexican Valium.
Once you use Lunesta, there is an impact on your health. Severe physical and psychological side effects can occur because of Lunesta abuse.
Short-term side effects of Lunesta abuse may include:
- Coordination impairment.
- Depression.
- Memory loss.
Lunesta Detox Timeline
The withdrawal timeframe for Lunesta might vary considerably. To begin with, persons who used Lunesta briefly and in tiny dosages may not experience withdrawal symptoms. On the other hand, people who have used the medication too much and for a long time may have withdrawal symptoms. These symptoms can last for weeks or even months.
Most patients experience withdrawal symptoms one to two days after their final Lunesta dosage. Anxiety and sleeplessness are common first symptoms. Lunesta withdrawal symptoms often peak between three and seven days. Most people’s symptoms improve within three weeks and finally vanish. If you rely on Lunesta, you might have withdrawal symptoms for up to eight weeks after your last dose.
A planned detox is the best way to deal with your withdrawal symptoms. Many people try to detox on their own in their own homes. Unfortunately, they might face worse side effects that last longer without medical help. Most severe withdrawal symptoms come from people who tried detoxing on their own. Instead of making things better, it progressively made things worse. Therefore, medical detox is beneficial.
If you’re struggling with addiction to Lunesta, our qualified Lunesta detox treatment center can help. Turn to We Level Up for compassionate recovery services.
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7/365 Line (844) 597-1011Lunesta Usage Statistics
Lunesta (eszopiclone) is a prescription medicine for insomnia. However, it can be habit-forming if used for an extended period or in higher doses than prescribed. Lunesta addiction shows a strong need to seek the drug. This happens even when there are bad effects and withdrawal symptoms when stopping. It’s not an illegal drug. However, the statistics below show that sedatives like Lunesta can cause serious problems. One of these problems is drug dependency.
10 Million
The CDC estimates that 10 million people in the US take prescription sleep medications. One example of these medications is Lunesta.
Source: CDC
21 Million
A study by the FDA found that around 21 million people in the US have misused prescription sleeping pills. This includes drugs like Lunesta.
Source: FDA
1.9 Million
In 2018, roughly 1.9 million individuals aged 12 or older reported misusing sedatives, including Lunesta. Misusing sedatives can lead to substance use disorder, dependence, and other health problems.
Source: NSDUH
Top 5 Lunesta Detox Studies with Insights
Here is a helpful list of trusted Lunesta detox studies and guidance. Each row distills the evidence’s implications for treatment into actionable tips for care teams and admissions scripts. Sources were chosen for recency, rigor, and relevance to integrated treatment.
| Study | Treatment Implications | Insights for Patients |
|---|---|---|
| American Addiction Centers – Lunesta Treatment View Study | Detox in a controlled medical environment for severe dependence or misuse. | Patients receive safety monitoring and support during withdrawal. |
| The study looks at how common withdrawal symptoms are after 24 weeks of eszopiclone treatment. It focuses on patients with chronic insomnia. This is a prospective, interventional study from 2021. View Resource | After 24 weeks of using eszopiclone, withdrawal symptoms may happen when you stop taking it. Clinicians should anticipate and monitor for withdrawal, especially in patients who exhibit dependence or poor compliance. Tapering rather than abrupt discontinuation is safer. | If you have used Lunesta every night for about 6 months, there is a 10% chance you may feel mild to moderate withdrawal symptoms. These can include fatigue, weakness, anxiety, and jitteriness. |
| Eszopiclone Co‑Administered With Fluoxetine in Patients With Insomnia Coexisting With Major Depressive Disorder (2006). Read Article | Using Lunesta together with an antidepressant (fluoxetine) may help with both sleep and mood symptoms. For patients with depression + insomnia, combining treatment may provide faster antidepressant effects. Stopping Lunesta after about 8 weeks does not seem to cause rebound depression or major withdrawal. This remains true as long as the antidepressant treatment continues. | If you have depression and trouble sleeping, taking Lunesta with your antidepressant may help you sleep better. It could also help improve your mood faster. |
| Evaluation of eszopiclone discontinuation after cotherapy with fluoxetine for insomnia with coexisting depression. J Clin Sleep Med. 2007. Read Study | Shows that after co‑therapy with eszopiclone + fluoxetine, discontinuing Lunesta did not lead to substantial rebound insomnia or depressive symptoms in the short follow‑up (2 weeks). | You may not have strong withdrawal effects or rebound depression if you stop Lunesta after a short time. This is true if you keep taking your antidepressant. |
| A 12-week study tested the effect of eszopiclone 2 mg on sleep in older adults. This study was randomized, double-blind, and placebo-controlled. It focused on adults with primary and comorbid insomnia. Read Review | Eszopiclone 2 mg taken at night helps older adults fall asleep faster. It also increases total sleep time and reduces the frequency of waking after sleep. This benefit is seen in people with primary insomnia and those with other sleep issues. | Using Lunesta (eszopiclone 2 mg) for a short time (about 3 months) can help you fall asleep faster. It can also help you stay asleep longer and reduce wake-ups, especially in older adults. This is true even if you have other health issues that impact your sleep. |
Importance Of A Lunesta Detox Program
Lunesta detox is removing toxins from the body, such as abused drugs. Detoxification can happen in a residential or inpatient setting. This choice depends on how severe the Lunesta withdrawal effects are and how much support is needed. Generally, Lunesta detoxification involves the following steps:
- Assessment: A healthcare professional will assess your physical and mental health and the extent of your substance use. They will also assess any underlying medical or mental health conditions that may impact your detoxification process.
- Medication: Depending on your symptoms, your healthcare provider may prescribe medication to manage your withdrawal symptoms. In the case of Lunesta detox, this may include tapering off the medication gradually over a period of weeks.
- Support: Lunesta detox can be challenging, and having a support system can be helpful. This may include individual or group therapy, family counseling, and peer support groups.
- Monitoring: During the Lunesta detox, your doctor will check your vital signs and mental health. This is to ensure your safety and comfort.
Medical Lunesta Detox
Lunesta detox can be very uncomfortable and causes many people to relapse to relieve unpleasant withdrawal symptoms. Medical detox programs reduce the likelihood of relapse because clients are housed in a supportive and sober environment. If you are worried about suffering from the side effects of Lunesta withdrawal, there is an easy solution. Instead of facing the issue alone, you can work with a local detox center.
The safest way to manage withdrawal symptoms is to taper down the dosage gradually. It is best to taper down Lunesta under the supervision of a physician. Slowly tapering off Lunesta can help avoid the most severe withdrawal symptoms and medical consequences.
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(844) 597-1011Lunesta Detox Treatment
The We Level Up research has helped us create a simple withdrawal timeline. This timeline may assist you as you deal with Lunesta withdrawal symptoms. A significant warning sign is withdrawal symptoms lasting over a month and a half. This is usually a sign that you need help with the Lunesta detox. Once again, this comes down to the simple fact that everyone’s bodies are different. And that other people can react to the drug and withdrawal in many ways. Keep in mind that professional detoxing can also be a preventative measure. Do not wait until you are in excruciating pain to seek expert assistance.
Stages of Lunesta Detox
We Level Up’s medically supervised Lunesta detox occurs across three distinct stages. Each stage targets different elements of the Lunesta withdrawal process and helps people achieve physical and mental health.
Assessment
The medical team will thoroughly assess you when you first enter our Lunesta detox program. This includes asking questions about your history of Lunesta use, such as:
- How long have you used Lunesta?
- What was your typical Lunesta dose?
- How frequently do you use Lunesta?
- Do you have a family history of addiction?
- Do you use illicit drugs or alcohol in addition to Lunesta?
This interview helps our team make a personalized treatment plan. It will focus on common Lunesta withdrawal symptoms you might have.
This stage helps our team find any medical or mental health issues that could affect your treatment. Lunesta can cause physical withdrawal symptoms. These symptoms can make problems worse. It is important for our team to find and treat any existing conditions.
Once our team finishes the assessment and diagnosis, they will make a treatment plan for you to start right away. This detox stage starts on the first day, usually just hours after you arrive. This way, you can begin targeted treatment right away.
Stabilization
The stabilization phase is most of a client’s time at our Lunesta detox center. During this stage, clients are under 24/7 medical observation and receive targeted treatments to help reduce Lunesta withdrawal symptoms. The rebound symptoms from suddenly stopping Lunesta can be severe. A medically supervised detox involves administering targeted medications to alleviate these symptoms. Treatment typically lasts between one and two weeks.
Clients live on-site at our treatment facility during stabilization to receive around-the-clock care. Our medical team observes to identify and treat any physical and psychological withdrawal symptoms as they occur. Furthermore, our team takes care of your needs throughout your treatment stay. Medical detox is an all-inclusive experience, so you can focus your energy on healing and feeling better.
Transition
The final stage of Lunesta detox is the transition to the next level of care. People with Lunesta addiction may need ongoing treatment to stay sober after medical detox. Treating physical withdrawal symptoms alone is not enough for long-term recovery.
We Level Up provides complete care for people needing addiction treatment. We make the transition process as smooth as possible. Once you have stabilized from Lunesta withdrawal, our team will get you ready for follow-up treatment. This will be at a residential or inpatient center. We want to help you get the care you need for lasting sobriety.
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Treatment After Lunesta Detox
After finishing a Lunesta detox program, We Level Up offers different levels of care. These programs help people learn the skills they need for a lifetime of recovery. Each level of care provides evidence-based treatment for substance use disorders, but they do so in different formats. Understanding the differences can help you decide which class is suitable for you.
Residential Rehab
Residential rehab is the treatment of choice for people with severe addictions because it is the most intensive substance use treatment available. People in our residential rehab programs live on-site at one of our inpatient treatment facilities while receiving care.
During the day, clients receive intensive treatments and therapies to help them overcome addiction. This includes evidence-based services, such as:
- Individual therapy.
- Group therapy.
- Relapse-prevention programs.
- Motivational interviewing.
- Family therapy.
- Medication-assisted treatment.
- Experiential therapies.
These treatments help people learn skills to avoid relapse. They also teach healthy ways to cope with stress. This helps individuals build strong, healthy lives in recovery and stay away from substance use.
Partial Hospitalization Program (PHP)
We Level Up’s partial hospitalization programs offer all the same treatments and therapies as residential programs. The partial hospitalization program at We Level Up has clients attend treatment several days a week for several hours at a time. This helps our clients focus on building recovery tools early. This is when the risk of relapse is highest.
People often face real-life challenges impacting their recovery when they return home after daily treatment. One of the key benefits of a PHP program is that it allows people to use the skills they learn in therapy. This practical use of their skills can help people addicted to Lunesta. It can reinforce lessons from treatment and support their recovery.
Dual-Diagnosis Treatment
Many people with substance use disorders also have mental illness. This makes mental health treatment very important for those addicted to Lunesta. Dual-diagnosis treatment is designed to help people who have co-occurring substance abuse and mental health conditions, such as:
- Anxiety.
- Depression.
- Post-traumatic stress disorder.
- Attention deficit/hyperactivity disorder.
- Bipolar disorder.
- Obsessive-compulsive disorder.
Left untreated, these disorders can dramatically increase a person’s risk of relapse.
Dual-diagnosis treatment offers an elegant solution by integrating mental health services into an addiction treatment program. People in a dual-diagnosis program can get specific therapies for their mental health symptoms. They can also have detailed psychiatric evaluations. Additionally, they can receive targeted medications to help them with their mental health challenges.
Dual-diagnosis programs are available in hospitals and residential centers. They help people with co-occurring disorders reach better health through treatment.
Lunesta Detox Process
Medical detox is a relatively short procedure. You can reach them by contacting a reputable center. You will then meet with a specialized medical team to determine medication requirements. After you are prescribed medication, the detox process begins. Professionals will monitor you to help you deal with the withdrawal from Lunesta. The professionals can provide additional treatment if you develop mental conditions during withdrawal.
Improving the overall sleep quality may help avoid returning to drug abuse. A complete substance abuse program may teach many therapeutic, holistic, and complementary methods. Learning to naturally lower your heart rate and blood pressure will allow you to live without substance-related solutions.
Recovery from a Lunesta addiction is also aided by learning new methods to manage stress. And the ability to recognize potential triggers as they arise in everyday life. Family support and educational tools are helpful for addiction recovery as well.
At We Level Up treatment facility, we offer care with our doctors available 24/7. They are here to help you recover and succeed. Reclaim your life by contacting one of our therapy professionals. Our experts understand what you’re going through and will gladly answer any questions.
Your call will be confidential and private, and there will be no obligation.
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Top 3 Lunesta Addiction Withdrawal FAQs
-
Can Lunesta cause withdrawal symptoms?
Yes, Lunesta (eszopiclone) can cause withdrawal symptoms if taken regularly and then abruptly stopped or significantly reduced in dosage. Withdrawal symptoms can include rebound insomnia, anxiety, irritability, agitation, tremors, sweating, headaches, nausea, vomiting, and diarrhea.
-
How long is the Lunesta withdrawal duration?
Lunesta withdrawal symptoms usually begin a few days after you stop or lower your dose. These symptoms can last for several weeks. The tapering process can affect how bad and how long withdrawal symptoms last. This means slowly lowering the Lunesta dose to reduce the risk and severity of these symptoms. Tapering may be done over a period of days or weeks, depending on the individual’s needs and circumstances.
-
Can you take Lunesta for opiate withdrawal?
Lunesta is not generally recommended for use in opiate withdrawal. Lunesta is a medication that helps with sleep. It is a sedative-hypnotic, but it is not an opiate. It does not directly treat the symptoms of opiate withdrawal. Opiate withdrawal symptoms can include anxiety, restlessness, insomnia, muscle aches, nausea, vomiting, and diarrhea. Some medications can be used specifically to address these symptoms, such as buprenorphine, methadone, and clonidine. These medications attach to the same brain receptors as opiates. However, they help reduce withdrawal symptoms and cravings. They do this without causing the same euphoric effects as opiates.
It’s essential to work with a healthcare professional when undergoing opiate withdrawal, as withdrawal symptoms can be uncomfortable and potentially detrimental. A healthcare professional can help create a treatment plan just for you. They will also provide support and monitor you during the withdrawal process.
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Sources
Sources
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[3] LUNESTA® (eszopiclone) tablets – Accessdata.fda.gov – Food & Drug Administration (FDA)
[4] Inoue Y, Takaesu Y, Koebis M. Prevalence of and factors associated with acute withdrawal symptoms after 24 weeks of eszopiclone treatment in patients with chronic insomnia: a prospective, interventional study. BMC Psychiatry. 2021 Apr 14;21(1):193. DOI: 10.1186/s12888-021-03196-0. PMID: 33853571; PMCID: PMC8045275.
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[10] InformedHealth.org [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. Using medication: What can help when trying to stop taking sleeping pills and sedatives? 2010 Apr 20 [Updated 2017 Aug 10]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK361010/