Skip to content

Melatonin and Alcohol Interactions. Alcohol and Melatonin Effects. Melatonin and Alcohol Death Warning.

Mixing melatonin and alcohol can lead to extreme drowsiness, slowed breathing, impaired motor skills, memory problems, and an increased likelihood of accidents or injuries. It can even result in life-threatening situations, such as overdose or respiratory failure. Continue to read more about the risks of mixing melatonin and alcohol.

Dangers of Mixing Melatonin and Alcohol

Can you mix melatonin and alcohol? Mixing melatonin and alcohol can be harmful due to several reasons. Both substances have sedative effects, and combining them can result in excessive drowsiness, impaired coordination, and an increased risk of accidents.

The combination may worsen cognitive function, leading to poor judgment and decision-making abilities. Moreover, alcohol is a diuretic that can contribute to dehydration, which can aggravate melatonin’s mild diuretic effects. However, individual reactions to the combination can be unpredictable, making it difficult to gauge the overall impact on the body. Still, both substances are processed by the liver, and combining them may strain liver function, particularly in individuals with existing liver conditions or those taking medications affecting the liver.

Overall, it’s always better to seek professional medical advice when considering the combination of any medications or supplements with alcohol to ensure your safety and well-being.

Combining Melatonin Alcohol Warning

Mixing melatonin and alcohol can be potentially unsafe due to the following reasons:

  • Increased sedation: Both alcohol and melatonin have sedative effects on the central nervous system. These effects can be additive when melatonin and alcohol are mixed, leading to increased drowsiness, confusion, and impaired coordination. This can be particularly risky if you need to perform tasks that need alertness, such as driving or operating machinery.
  • Worsened cognitive function: Combining alcohol and melatonin can further impair cognitive function, including memory, attention, and decision-making. This can lead to poor judgment and an increased risk of accidents or injuries.
  • Increased risk of dehydration: Combined, they can potentially exacerbate dehydration, adversely affecting your body, including dizziness, fatigue, and electrolyte imbalances.
Can you overdose on melatonin? Yes. Melatonin overdose is rare but can occur if extremely high doses are taken. The risk is even higher when you combine melatonin and alcohol.
Can you overdose on melatonin? Yes. Melatonin overdose is rare but can occur if extremely high doses are taken. The risk is even higher when you combine melatonin and alcohol.
  • Unpredictable reactions: Can you mix alcohol and melatonin? Individuals may have varying tolerances and sensitivities to alcohol and melatonin. Combining the two substances can result in unexpected reactions, making determining how your body will respond difficult. This can heighten the likelihood of experiencing adverse effects or exacerbate existing health conditions.
  • Impaired liver function: Both alcohol and melatonin are processed by the liver. Consuming alcohol can strain the liver, and combining it with melatonin may further increase the burden on this organ. Individuals with pre-existing liver conditions or taking medications that affect liver function should be particularly cautious.

Melatonin and Alcohol Death

Can you drink alcohol with melatonin? While there are potential risks associated with mixing melatonin and alcohol, the combination does not typically lead directly to death. However, exercising caution and understanding the potential dangers is essential.

Excessive alcohol consumption, even without melatonin, can be life-threatening. Alcohol poisoning, which can result from consuming a toxic amount of alcohol, may cause severe impairment of the central nervous system, respiratory depression, and other critical health complications. It can be fatal if not promptly addressed and treated.

Unfortunately, many are mixing alcohol with medications to self-medicate or to obtain more significant desired effects. It is a concerning practice that can have severe consequences. Alcohol can interact negatively with many medications, reducing their effectiveness or amplifying their side effects. This can lead to unpredictable reactions, worsening existing health conditions, or new health complications.

What is Melatonin? Drug Facts

Generic Name: Melatonin [ meh-lah-TOE-nin ]
FDA Status: The FDA does not regulate supplements, such as melatonin.
Drug Classes:
Electrolytes and minerals, miscellaneous anxiolytics, sedatives and hypnotics, nutraceuticals, and supplements.

Melatonin and Alcohol Interactions

Studies have shown that combining melatonin and alcohol can affect sleep, cognition, and overall health. Both alcohol and melatonin can impact the central nervous system individually, but combined use can enhance sedative effects.

Research suggests this combination can further disrupt sleep patterns, affecting sleep quality and duration. Moreover, the additive sedative effects may increase the risk of accidents, falls, and other injuries due to impaired coordination and judgment.

Moreover, the metabolism of alcohol and melatonin can be influenced by each other. Alcohol can alter melatonin’s metabolism, affecting its effectiveness and duration of action. Conversely, melatonin may influence the metabolism of alcohol, potentially prolonging its presence in the body and delaying its elimination.

10 mg Melatonin and Alcohol

Combining 10 mg of melatonin with alcohol can increase both substances’ potential risks and side effects. This specific melatonin dosage is relatively high because the recommended dosage ranges from 0.5 to 5 mg.

However, 5mg melatonin and alcohol cannot be considered safe as mixing drugs or supplements with alcohol causes unpredictable body reactions.

How Long After Taking Melatonin Can I Drink Alcohol?

As a general guideline, it is advisable to allow a sufficient gap between taking melatonin and drinking alcohol to minimize potential interactions and risks.

Melatonin is a naturally occurring hormone supporting and regulating sleep-wake cycles; its effects typically last several hours. The exact duration can vary among individuals, but it is commonly recommended to take melatonin around 30 minutes to 1 hour before the desired sleep time.

To minimize potential interactions and risks, it is generally recommended to avoid consuming alcohol within a few hours of taking melatonin. This allows sufficient time for the effects of melatonin to wear off and reduces the chances of intensified sedative effects and impaired cognitive function.

Can you have melatonin with alcohol? The effects of melatonin can vary from person to person. Suppose you have specific concerns or questions regarding the timing between taking melatonin and consuming alcohol. In that case, it is best to consult a healthcare treatment professional who can provide personalized advice based on your unique circumstances. They can offer guidance tailored to your needs and help you make informed decisions.

Ryan Zofay forming a circle and hugging friends.

Get Your Life Back

Find Hope & Recovery. Get Safe Comfortable Detox, Addiction Rehab & Dual Diagnosis High-Quality Care.

Hotline(844) 597-1011

Alcohol mixing with drugs is a significant problem in the United States, contributing to various health risks and complications. Mixing alcohol with certain medications and supplements can severely affect physical and mental health. It can lead to liver damage, cardiovascular complications, impaired judgment, heightened risk of accidents and injuries, and worsened mental health conditions.

The practice of taking melatonin with alcohol itself is hazardous. Indicating a more severe problem that leads to alcohol use disorder and addiction.


Alcohol poisoning resulted in an average of 2,200 deaths annually in the US from 2011 to 2019.

Source: CDC

2.9 Million

In 2019, approximately 2.9 million people aged 12 or older reported past-month use of alcohol and illicit drugs simultaneously.

Source: SAMHSA


Alcohol overdose affects people of all ages, but young adults between 35 and 64 tend to have the highest rates of alcohol poisoning deaths.

Source: NCBI

Can You Take Melatonin With Alcohol?

Is it bad to take melatonin with alcohol? Alcohol can interact negatively with various medications, and the combination with melatonin is no exception. It can lead to unpredictable reactions, reduced medication efficacy, or adverse effects. Considering these factors, it is generally recommended to avoid taking melatonin with alcohol.

If you have sleep concerns or require assistance with sleep-related issues, we recommend discussing alternative options with your healthcare provider. They can provide personalized advice and suggest safer strategies to help improve your sleep quality without the potential risks associated with combining melatonin and alcohol.

The We Level Up treatment centers help individuals with dual diagnosis problems. We understand that some individuals with mental health disorders may attempt to self-medicate their symptoms by using substances. They may use drugs or alcohol to temporarily alleviate feelings of anxiety, depression, or other emotional distress.

However, this self-medication can lead to a cycle of addiction and worsen the underlying mental health condition. Integrated treatment approaches that address addiction and mental health are often the most effective in promoting long-term recovery and overall well-being.

Alcoholism and mental health problems can create a vicious cycle where one condition exacerbates the other. Alcohol and substance abuse can lead to or worsen mental health symptoms, while untreated mental health issues can increase the risk of relapse or hinder recovery efforts.

Combining melatonin and alcohol can be a sign of a deeper problem. Seeking professional help from healthcare providers, addiction specialists, or mental health professionals is vital for comprehensive assessment, accurate diagnosis, and appropriate treatment planning.
Is melatonin safe with alcohol? Combining melatonin and alcohol can be a sign of a deeper problem. Seeking professional help from healthcare providers, addiction specialists, or mental health professionals is vital for comprehensive assessment, accurate diagnosis, and appropriate treatment planning.

Get Help. Get Better. Get Your Life Back.

Searching for an Accredited Drug and Alcohol Rehab Centers in Near You?

Even if you have failed previously and relapsed, or are in the middle of a difficult crisis, we stand ready to support you. Our trusted behavioral health specialists will not give up on you. When you feel ready or just want someone to speak to about therapy alternatives to change your life call us. Even if we cannot assist you, we will lead you to wherever you can get support. There is no obligation. Call our hotline today.

(844) 597-1011

Side Effects of Mixing Alcohol and Melatonin

Mixing alcohol and melatonin can lead to several potential side effects and risks. Here are some of the possible consequences:

  • Gastrointestinal Distress: Both alcohol and melatonin can have irritant effects on the digestive system. Mixing the two may lead to gastrointestinal symptoms such as nausea, vomiting, abdominal discomfort, and diarrhea.
  • Increased Risk of Accidents and Injuries: The combination of alcohol and melatonin can increase the risk of accidents and injuries due to sedative effects and impaired coordination. Activities that require focus and physical coordination, such as driving, can become extremely dangerous.
  • Increased Sedation: Together, they can intensify each other’s sedative properties, increasing drowsiness and lethargy. This can impair coordination, slow reaction times, and make tasks such as driving or operating machinery dangerous.
  • Impaired Cognitive Function: Is it safe to take melatonin with alcohol? Combining alcohol and melatonin can impair cognitive function and mental alertness. It may result in confusion, difficulty concentrating, and memory problems. This can impact judgment and decision-making abilities.
  • Interference with Medications: Alcohol can interact negatively with various medications, including melatonin. It can alter the metabolism and effectiveness of melatonin, potentially reducing its desired effects or causing unpredictable reactions.

Can you take melatonin and alcohol? The severity and individual response to mixing alcohol and melatonin can vary. Some individuals may be more sensitive to the effects, while others may tolerate the combination better. However, due to the potential risks involved, it is generally recommended to avoid mixing alcohol and melatonin.

First-class Facilities & Amenities

World-class High-Quality Addiction & Mental Health Rehabilitation Treatment

Rehab Centers Tour

Renowned Addiction Centers. Serene Private Facilities. Inpatient rehab programs vary.

Addiction Helpline(844) 597-1011

Proven recovery success experience, backed by a Team w/ History of:

  • 15+ Years Experience
  • 100s of 5-Star Reviews
  • 10K+ Recovery Successes
  • Low Patient to Therapist Ratio
  • Onsite Medical Detox Center
  • Comprehensive Dual-Diagnosis Treatment
  • Complimentary Family & Alumni Programs
  • Coaching, Recovery & Personal Development Events

Alcohol Use Disorder Treatment

Alcohol misuse with other medications is a severe problem that requires appropriate treatment. Mixing alcohol with certain medications can lead to harmful interactions, intensified side effects, and increased health risks.

If you are experiencing difficulties with alcohol drinking, it is crucial to seek help. Alcohol problems can significantly impact your physical and mental health, relationships, and overall well-being. Contact healthcare professionals, addiction specialists, or support groups who can provide guidance, support, and treatment options. Remember, seeking help is a brave and essential step towards recovery and leading a healthier, happier life.

If you don’t know where to start, We Level Up is ready to help. We can help you explore treatment options and resources. Each call is private and confidential, and there is no obligation.

World-class, Accredited, 5-Star Reviewed, Effective Addiction & Mental Health Programs. Complete Behavioral Health Inpatient Rehab, Detox plus Co-occuring Disorders Therapy.

CALL(844) 597-1011

End the Addiction Pain. End the Emotional Rollercoaster. Get Your Life Back. Start Drug, Alcohol & Dual Diagnosis Mental Health Treatment Now. Get Free No-obligation Guidance by Substance Abuse Specialists Who Understand Addiction & Mental Health Recovery & Know How to Help.

Top 5 Melatonin & Alcohol FAQs

  1. Can I take melatonin with alcohol?

    It is generally recommended to avoid taking melatonin with alcohol due to potential interactions and increased sedative effects.

  2. Can I mix melatonin and alcohol?

    It is crucial to be aware of the risks involved, such as excessive drowsiness and impaired cognitive function, and to make an informed decision based on your health and safety.

  3. How long after alcohol can I take melatonin?

    It is generally advised to wait several hours after consuming alcohol before taking melatonin to allow the effects of alcohol to wear off. This minimizes potential interactions and avoids intensifying sedative effects or impairing cognitive function. It is best to consult with a healthcare professional for personalized advice regarding the specific timing between alcohol consumption and taking melatonin.

  4. What happens if you take melatonin with alcohol?

    Taking melatonin with alcohol can intensify sedative effects, leading to increased drowsiness, impaired coordination, and cognitive dysfunction. This combination may increase the risk of accidents, falls, and other injuries due to reduced alertness and compromised motor skills.

  5. Can you take melatonin after drinking alcohol?

    Wait until the influence and effects of alcohol have worn off and your blood alcohol concentration has returned to a safe level before taking melatonin to minimize potential interactions and risks.

Alcohol Poisoning Symptoms, Signs, Cures, Effects & What To Do?

Melatonin mixed with alcohol can potentially have adverse effects, although it is not directly associated with alcohol intoxication. Alcohol poisoning occurs when an individual drinks or consumes a toxic amount of alcohol, leading to a dangerous suppression of the central nervous system.

However, both alcohol and melatonin can cause sedation and drowsiness, and combining them can intensify these effects. This combination may impair cognitive and motor functions, leading to increased drowsiness, dizziness, coordination difficulties, and an increased risk of accidents.

Watch the video below to identify a case of alcohol poisoning.

If you or a loved one is struggling with alcohol addiction or other substance use disorder(s), call for a FREE consultation 24/7 at (561) 678-0917

Get FREE addiction treatment insurance check –

Alcohol Poisoning Symptoms Video Transcript.

Welcome to the We Level Up treatment center video series. In today’s video, we will discuss Alcohol Poisoning Symptoms, Signs, Cures, Effects & What To Do?

Drinking much alcohol quickly can have dangerous and fatal side effects, such as alcohol poisoning. A coma or death may result from too much alcohol too quickly, affecting respiration, heart rate, body temperature, and gag reflex.

Severe alcohol intoxication necessitates immediate medical attention. If you believe someone may have alcohol poisoning, call 911 to obtain immediate emergency medical care.

When to visit a doctor for alcohol poisoning?

Not all of the warning signs or symptoms of alcohol poisoning must occur before you seek medical help. It is important to note that patients with alcohol poisoning who are dozing off or who cannot be awakened risk dying.

Alcohol poisoning is an urgent situation.

If you have any suspicions, even if you don’t notice the classic symptoms or indicators of alcohol poisoning, you should get immediate medical help. What you need to do for alcohol poisoning is:

Dial your local emergency number or 911 right away. Never rely on someone recovering from alcohol poisoning to sleep.

Be prepared to share details. If you are aware, let medical staff or emergency workers know what kind, how much, and when the patient drank alcohol.

Never leave a person who is unconscious alone. Someone with alcohol poisoning may choke on their vomit and become unable to breathe because alcohol poisoning alters how the gag reflex functions. Don’t try to make the victim throw up while you wait for assistance; you risk making them choke.

Help someone who is throwing up. Make an effort to keep the person seated. Turn the person’s head to the side if they must lie down; this will help them from choking. To prevent unconsciousness, make an effort to keep the person awake.

Experience Transformative Recovery at the We Level Up Treatment Center.

See our authentic success stories. Get inspired. Get the help you deserve.

We Level Up Treatment Centers for Drug Alcohol Rehab Detox Behavioral Mental Health Dual Diagnosis TherapyWe Level Up Treatment Centers for Drug Alcohol Rehab Detox Behavioral Mental Health Dual Diagnosis TherapyWe Level Up Treatment Centers for Drug Alcohol Rehab Detox Behavioral Mental Health Dual Diagnosis Therapy

Hotline (844) 597-1011

Start a New Life

Begin with a free call to an addiction & behavioral health treatment advisor. Learn more about our dual-diagnosis programs. The We Level Up treatment center network delivers recovery programs that vary by each treatment facility. Call to learn more.

  • Personalized Care
  • Caring Accountable Staff
  • World-class Amenities
  • Licensed & Accredited
  • Renowned w/ 100s 5-Star Reviews

We’ll Call You

Search We Level Up Melatonin and Alcohol Detox, Mental Health Topics & Resources

[1] National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 896, Melatonin. Retrieved June 27, 2023, from

[2] Melatonin: What You Need To Know – National Center for Complementary and Integrative Health (NCCIH)

[3] Kurhaluk N. Alcohol and melatonin. Chronobiol Int. 2021 Jun;38(6):785-800. doi 10.1080/07420528.2021.1899198. Epub 2021 Mar 24. PMID: 33761823.

[4] Gendy MNS, Lagzdins D, Schaman J, Le Foll B. Melatonin for Treatment-Seeking Alcohol Use Disorder patients with sleeping problems: A randomized clinical pilot trial. Sci Rep. 2020 May 26;10(1):8739. doi 10.1038/s41598-020-65166-y. PMID: 32457492; PMCID: PMC7250869.

[5] FDA About Melatonin – Food & Drug Administration (FDA)

[6] Sleep Aids and Stimulants (Continued) – Centers for Disease Control and Prevention (CDC)

[7] Melatonin: MedlinePlus Supplements –

[8] Lie JD, Tu KN, Shen DD, Wong BM. Pharmacological Treatment of Insomnia. P T. 2015 Nov;40(11):759-71. PMID: 26609210; PMCID: PMC4634348.

[9] Hu Z, Oh S, Ha TW, Hong JT, Oh KW. Sleep-Aids Derived from Natural Products. Biomol Ther (Seoul). 2018 Jul 1;26(4):343-349. doi 10.4062/biomolther.2018.099. PMID: 29929351; PMCID: PMC6029681.

[10] Sleep Disorder (Sedative-Hypnotic) Drug Information – Food & Drug Administration (FDA)

Table of Contents