Skip to content

Atypical Antidepressants for Depression and Anxiety. Natural Antidepressants Supplements.

Atypical antidepressants treat depression and bipolar disorder. Atypical antidepressants work in different ways than conventional ones, which focus on serotonin and norepinephrine. The mechanisms of action of atypical antidepressants for depression and bipolar illness will be discussed in this article.

Atypical Antidepressants

Depression and bipolar illness are treated with various medicines in the atypical antidepressant class. Atypical antidepressants are effective in various ways, as opposed to the only focus on serotonin and norepinephrine by conventional antidepressants. This article will discuss the use of atypical antidepressants in treating depression and bipolar disorder and their mechanisms of action.

We Level Up Treatment Center offers comprehensive depression medication treatment options designed to relieve its distressing symptoms.

Atypical Antidepressants List

Atypical antidepressants are a group of medications that do not fit the conventional classification of selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or tricyclic antidepressants (TCAs). Instead, they encompass a wide range of drugs with unique mechanisms of action. Some of the commonly prescribed atypical antidepressants include:

  • Bupropion (Wellbutrin): Bupropion is known for its impact on norepinephrine and dopamine. It is often used to treat depression and can be particularly beneficial for individuals concerned about sexual side effects associated with other antidepressants.
  • Mirtazapine (Remeron): Mirtazapine primarily affects serotonin and norepinephrine. It is used to address both depression and, at times, sleep disturbances related to depression.
  • Trazodone (Oleptro): Trazodone is often prescribed off-label for insomnia related to depression. It modulates serotonin receptors and can improve sleep quality.
  • Vilazodone (Viibryd): This medication targets serotonin regulation and treats major depressive disorder (MDD).
  • Nefazodone (Serzone): Nefazodone influences serotonin and norepinephrine and manages depression.

Are Natural Antidepressants Considered as Atypical Depressants?

Natural antidepressants are not typically considered atypical antidepressants in the same way that prescription medications like bupropion (Wellbutrin), mirtazapine (Remeron), and trazodone (Oleptro) are. Atypical antidepressants, as the name suggests, refer to a specific category of prescription medications that work differently from traditional SSRIs (Selective Serotonin Reuptake Inhibitors) or other common antidepressants. These medications often have distinct mechanisms of action and side effect profiles.

Natural antidepressants, on the other hand, typically refer to natural remedies, supplements, or lifestyle changes that are sometimes used to help manage symptoms of depression or improve mood. atypical antidepressants examples might include:

  1. St. John’s Wort: Some people use an herbal supplement for mild to moderate depression.
  2. Omega-3 Fatty Acids: Found in fatty fish and some dietary supplements, they are believed to have mood-boosting properties.
  3. Exercise: Regular physical activity improves mood and can be considered a natural antidepressant.
  4. Dietary Changes: A balanced diet rich in whole foods, particularly those containing tryptophan, can positively impact mood.

While these natural remedies may potentially improve mood and alleviate depressive symptoms, they are not prescription medications, and their efficacy can vary widely from person to person. Additionally, they do not fall under the category of atypical antidepressants in the same way that prescription medications do.

Side Effects of Atypical Antidepressants

Side EffectDescription
Common Side Effects
NauseaMay occur; often manageable with food.
Dry MouthCommon; stay hydrated and use sugar-free lozenges.
DizzinessRisk when standing up quickly; rise slowly.
Weight ChangesSome cause weight gain, while others may lead to weight loss.
Sexual Side EffectsLower risk than traditional antidepressants, but still possible.
Sleep DisturbancesSome improve sleep quality, while others may cause disturbances.
Less Common Side Effects
HeadachesOccasional side effect.
ConstipationPossible, especially with anticholinergic medications.
SweatingExcessive sweating, particularly at night.
AgitationRare cases of increased restlessness or agitation.
Skin ReactionsInfrequent, but skin rashes or reactions can occur.
Serious Side Effects
Allergic ReactionsAn emergency with symptoms like hives and difficulty breathing.
SeizuresAssociated with bupropion, especially at higher doses.
Changes in MoodRarely, mood changes, anxiety, or suicidal thoughts may occur.
Atypical Antidepressants Side-Effects

Get Help. Get Better. Get Your Life Back.

Searching for an Accredited Drug and Alcohol Rehab Centers in Near You?

Even if you have failed previously and relapsed, or are in the middle of a difficult crisis, we stand ready to support you. Our trusted behavioral health specialists will not give up on you. When you feel ready or just want someone to speak to about therapy alternatives to change your life call us. Even if we cannot assist you, we will lead you to wherever you can get support. There is no obligation. Call our hotline today.

(844) 597-1011

Discover Effective Antidepression Medications at We Level Up Treatment Centers

Conquering Depression and Anxiety can feel isolating and arduous. Many individuals struggle to navigate this condition without support and frequently relapse in their efforts to manage symptoms.

View more We Level Up treatment centers.

Atypical Antidepressants

We Level Up Fort Lauderdale

Premier Behavioral Health Treatment Center

Licensed & Accredited w/ 5-star reviews.
  • Inpatient mental health treatment center
  • Therapy for depression, anxiety, trauma, bipolar disorder, PTSD, and more.
  • Dual diagnosis rehab programs available
Fort Lauderdale Mental Health Center
Atypical Antidepressants

West Palm Beach (coming soon)

Premier Behavioral Health Treatment Center

Coming soon (licensed & accredited.)
  • Inpatient mental health treatment center
  • Therapy for depression, anxiety, trauma, bipolar disorder, PTSD, and more.
  • Dual diagnosis rehab programs available
West Palm Beach Mental Health Center
Atypical Antidepressants

We Level Up Washington

Premier Behavioral Health Treatment Center

Licensed & Accredited w/ 5-star reviews.
  • Inpatient mental health treatment center
  • Therapy for depression, anxiety, trauma, bipolar disorder, PTSD, and more.
  • Dual diagnosis rehab programs available
Washington Mental Health Center

Atypical Antidepressants Fact Sheet

What are Atypical Antidepressants?

Atypical antidepressants are a category of antidepressant medications that don’t fit the traditional classifications of SSRIs, SNRIs, or TCAs. They work in unique ways to relieve symptoms of depression and, in some cases, bipolar disorder.

Common Atypical Antidepressants

  1. Bupropion (Wellbutrin): Known for its stimulant properties and often prescribed to combat depression and help with smoking cessation.
  2. Mirtazapine (Remeron): Often used for its sedative properties and appetite-stimulating effects.
  3. Trazodone (Oleptro): Primarily prescribed to treat insomnia but may also be used to manage depression.

How Atypical Antidepressants Work

Atypical antidepressants modulate various neurotransmitters in the brain, leading to an improvement in mood and a reduction in depressive symptoms. Their mechanisms of action may include increasing norepinephrine and dopamine levels.

Atypical Antidepressants Benefits

  • Lower risk of sexual side effects compared to traditional antidepressants.
  • Different side effect profiles provide options for those who don’t respond well to other medications.
  • It can be effective in treating depression and sometimes bipolar disorder.

Atypical Antidepressants Considerations

  • Atypical antidepressants have side effect profiles, so discussing potential side effects with your healthcare provider is crucial.
  • Effectiveness can vary between individuals; finding the proper medication and dosage may take time.
  • Some atypical antidepressants, like bupropion, may have stimulant effects.

Common Side Effects

  • Nausea.
  • Dry mouth.
  • Dizziness.
  • Weight changes.
  • Sleep disturbances.

Less Common Side Effects

  • Headaches.
  • Constipation.
  • Sweating.
  • Agitation.
  • Skin reactions.

Serious Side Effects

  • Allergic reactions.
  • Seizures (associated with bupropion).
  • Changes in mood, including anxiety and suicidal thoughts (rare).

Atypical Antidepressants for Depression Statistics

One of the most prevalent mental diseases in the US is significant depression. Some people with severe depression may experience substantial impairments that impede their capacity to engage in meaningful life activities.

21 million

An estimated 21.0 million adults in the United States had at least one major depressive episode. This number represented 8.4% of all U.S. adults.

Source: National Institute on Mental Health


The prevalence of major depressive episodes was higher among adult females (10.5%) than males (6.2%).

Source: National Institute on Mental Health


The prevalence of adults with a major depressive episode was highest among individuals aged 18-25 (17.0%).

Source: National Institute of Mental Health

Can Natural Antidepressants Food be Used as An Alternative?

Natural antidepressants, often referred to as natural remedies or alternative therapies, are sometimes considered by individuals as an alternative to conventional antidepressant medications. These natural alternatives to antidepressants typically focus on lifestyle, dietary, and holistic methods to manage symptoms of depression or enhance overall well-being. However, it’s essential to understand that they may not be suitable for everyone, and their effectiveness can vary from person to person. Here are some points to consider:

People may choose natural antidepressants, sometimes known as alternative therapy, instead of traditional pharmaceuticals. These natural treatments focus on lifestyle, food, and holistic strategies to control depression or improve well-being.
People may choose natural antidepressant foods, sometimes known as alternative therapy, instead of traditional pharmaceuticals. These natural treatments focus on lifestyle, food, and holistic strategies to control depression or improve well-being.
  • Lifestyle Modifications: Incorporating regular physical activity, maintaining a balanced diet, ensuring adequate sleep, and reducing stress can positively impact mood and overall mental health. These are often recommended as complementary strategies alongside other treatments.
  • Dietary Supplements: Some dietary supplements, such as omega-3 fatty acids (found in fish oil), folate, and S-adenosylmethionine (SAMe), have been studied for their potential benefits in managing depressive symptoms.
  • Mind-Body Practices: Techniques like mindfulness meditation, yoga, and tai chi can help improve mood and reduce stress. They are often used as part of a comprehensive treatment plan.
  • Herbal Remedies: Certain herbal supplements, such as St. John’s Wort and Saffron, have shown promise in addressing mild to moderate depression. However, they can interact with other medications and have side effects, so it’s crucial to consult a healthcare provider.
  • Light Therapy: Light therapy, often used for Seasonal Affective Disorder (SAD), involves exposure to bright light and may help regulate mood in some cases.
  • Acupuncture and Massage: Some individuals find relief from depression and anxiety through acupuncture or therapeutic massage.

Natural antidepressants should be used cautiously, and a medical practitioner should be consulted before any significant adjustments are made to a patient’s medication regimen. Depression that is severe or long-lasting requires therapy, and while natural remedies may be recommended as part of a broader approach, they should not be relied upon alone. Clinical depression and bipolar disorder are typically more effectively treated with antidepressant drugs given by a healthcare provider.

Ryan Zofay forming a circle and hugging friends.

Get Your Life Back

Find Hope & Recovery. Get Safe Comfortable Detox, Addiction Rehab & Dual Diagnosis High-Quality Care.

Hotline(844) 597-1011

Antidepressants for Atypical Depression

Antidepressants can be an effective treatment option for atypical depression, a subtype of major depressive disorder. Atypical depression is characterized by symptoms that differ from those of typical depression. These symptoms often include mood reactivity (an improved mood in response to positive events), increased appetite, excessive sleep, leaden paralysis (a heavy feeling in the arms or legs), and interpersonal sensitivity. Here’s a brief overview of how antidepressants are used in the treatment of atypical depression:

1. MAOIs (Monoamine Oxidase Inhibitors): MAOIs are a class of antidepressants that can be particularly effective for atypical depression. Phenelzine and tranylcypromine are commonly prescribed MAOIs. They work by inhibiting the enzyme monoamine oxidase, which breaks down neurotransmitters like serotonin and norepinephrine. MAOIs can be especially helpful for individuals with atypical depression who do not respond well to other antidepressants.

2. SSRIs (Selective Serotonin Reuptake Inhibitors): SSRIs like fluoxetine, sertraline, and escitalopram are commonly prescribed for various types of depression, including atypical depression. They increase serotonin levels in the brain, which can help regulate mood and alleviate depressive symptoms. However, some individuals with atypical depression may not respond as well to SSRIs as other antidepressants.

3. Tricyclic Antidepressants: Tricyclic antidepressants like imipramine and nortriptyline are older antidepressants that can also be used for atypical depression. They affect multiple neurotransmitters in the brain and may be effective when other treatments have failed.

4. Bupropion: Bupropion is an atypical antidepressant that affects norepinephrine and dopamine. It is often considered when sexual side effects or weight gain associated with other antidepressants are concerns.

5. Other Medications: In some cases, medications like mirtazapine or venlafaxine, which have unique mechanisms of action, may be considered for atypical depression.

The choice of antidepressant for atypical depression depends on the individual’s specific symptoms, medical history, and any other medications they may be taking. Individuals with atypical depression must work closely with a mental health professional to determine the most suitable treatment approach. Psychotherapy, particularly cognitive-behavioral therapy (CBT), may also be recommended with antidepressant medication to address symptoms and improve overall well-being.

First-class Facilities & Amenities

World-class High-Quality Addiction & Mental Health Rehabilitation Treatment

Rehab Centers Tour

Renowned Addiction Centers. Serene Private Facilities. Inpatient rehab programs vary.

Addiction Helpline(844) 597-1011

Proven recovery success experience, backed by a Team w/ History of:

  • 15+ Years Experience
  • 100s of 5-Star Reviews
  • 10K+ Recovery Successes
  • Low Patient to Therapist Ratio
  • Onsite Medical Detox Center
  • Comprehensive Dual-Diagnosis Treatment
  • Complimentary Family & Alumni Programs
  • Coaching, Recovery & Personal Development Events

Safety Issues From Using Atypical Antidepressants

Currently, there is no medication specifically labeled as “fast-acting” for OCD (Obsessive-Compulsive Disorder) in the way that pain relievers might be fast-acting. It usually takes a while for the full effects of anti-OCD medication to kick in. Most antidepressants and selective serotonin reuptake inhibitors (SSRIs) used for obsessive-compulsive disorder (OCD) take a few weeks to show their full therapeutic effects.

Remember that getting well while being treated for OCD is a slow process. Treatments may not provide instantaneous relief like other treatments but can relieve symptoms dramatically over time. Cognitive Behavioral Therapy (CBT) can help you learn to manage and cope with your OCD symptoms before the meds take effect.

Let’s say you’re seeking a way to deal with a sudden emotional crisis as soon as possible. In that scenario, it’s best to talk to a doctor about how to proceed with treatment, whether that involves counseling, possible short-term measures, or medication.

World-class, Accredited, 5-Star Reviewed, Effective Addiction & Mental Health Programs. Complete Behavioral Health Inpatient Rehab, Detox plus Co-occuring Disorders Therapy.

CALL(844) 597-1011

End the Addiction Pain. End the Emotional Rollercoaster. Get Your Life Back. Start Drug, Alcohol & Dual Diagnosis Mental Health Treatment Now. Get Free No-obligation Guidance by Substance Abuse Specialists Who Understand Addiction & Mental Health Recovery & Know How to Help.

OCD and Depression Treatment Medication

The primary classes of medications used for treating Obsessive-Compulsive Disorder (OCD) are antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), and in some cases, other medications. It’s important to note that medication is usually just one part of a comprehensive treatment plan for OCD, which often includes therapy such as Cognitive Behavioral Therapy (CBT). Here are some commonly used OCD treatment medications:

  • Antipsychotic Medications (used as augmenting agents):
    • Aripiprazole (Abilify).
    • Risperidone (Risperdal).
    • Quetiapine (Seroquel).
  • Anti-Anxiety Medications (for short-term relief):
    • Benzodiazepines (e.g., Clonazepam, Lorazepam).
  • Augmentation Agents (used in combination with antidepressants):
    • Lamotrigine (Lamictal).
    • Buspirone (Buspar).
  • Selective Serotonin Reuptake Inhibitors (SSRIs):
    • Fluoxetine (Prozac).
    • Sertraline (Zoloft).
    • Paroxetine (Paxil).
    • Fluvoxamine (Luvox).
    • Escitalopram (Lexapro).
    • Citalopram (Celexa).
  • Tricyclic Antidepressant:
    • Clomipramine (Anafranil) – Particularly effective for OCD, though it may have more side effects than SSRIs.
  • Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs):
    • Venlafaxine (Effexor).
    • Duloxetine (Cymbalta).
  • Atypical Antidepressant:
    • Bupropion (Wellbutrin).

If you’re seeking professional help managing your depression, consider the specialized depression medication treatment programs available at We Level Up Treatment Center, where our experienced team is dedicated to supporting your journey of improved mental well-being.

Experience Transformative Recovery at the We Level Up Treatment Center.

See our authentic success stories. Get inspired. Get the help you deserve.

We Level Up Treatment Centers for Drug Alcohol Rehab Detox Behavioral Mental Health Dual Diagnosis TherapyWe Level Up Treatment Centers for Drug Alcohol Rehab Detox Behavioral Mental Health Dual Diagnosis TherapyWe Level Up Treatment Centers for Drug Alcohol Rehab Detox Behavioral Mental Health Dual Diagnosis Therapy

Hotline (844) 597-1011
Voluntarily testimonials from the We Level Up Treatment Center network vary. Not intended as a guaranteed treatment or outcome as each person's journey is unique.

Start a New Life

Begin with a free call to an addiction & behavioral health treatment advisor. Learn more about our dual-diagnosis programs. The We Level Up treatment center network delivers recovery programs that vary by each treatment facility. Call to learn more.

  • Personalized Care
  • Caring Accountable Staff
  • World-class Amenities
  • Licensed & Accredited
  • Renowned w/ 100s 5-Star Reviews

We’ll Call You

  1. How to get off antidepressants naturally?

    Tapering off antidepressants naturally should be done under the guidance of a healthcare provider. It often involves a slow reduction in dosage over time. Some strategies may include lifestyle changes, such as regular exercise, a balanced diet, stress management, and therapy.

  2. What conditions can atypical antidepressants treat?

    Atypical antidepressants can be used to treat major depressive disorder, seasonal affective disorder (SAD), generalized anxiety disorder, and some types of sleep disorders.

  3. Are atypical antidepressants commonly prescribed?

    The prescription rate for atypical antidepressants varies but has been steadily increasing in recent years. The choice of antidepressant depends on the individual’s specific condition and needs.

  4. Are natural antidepressants safe to use alongside prescription medications?

    Some natural remedies may interact with certain drugs, so professional guidance is recommended.

  5. Can natural antidepressants replace prescription medications?

    For some individuals with mild depression, natural antidepressants may be effective on their own. However, for more severe cases, they are often used as a complementary approach to traditional treatments rather than a replacement.

Tips for Maintaining Your Mental Well-being Informative Video

Video Script

We at We Level Up FL are dedicated to delivering personalized mental health services that cater to the unique needs of each individual. Our team of highly skilled professionals acknowledges that the path to mental well-being varies for each person. As a result, we work closely with our clients to create therapy programs that target their specific challenges and align with their objectives.

We strongly emphasize empathy and comprehension, providing unwavering support and guidance throughout the therapeutic journey. We strongly believe in empowering individuals to actively participate in their mental health by equipping them with the necessary tools and strategies to navigate their circumstances. We foster a secure, nurturing environment that encourages exploration, self-discovery, and personal growth.

Central to our approach is the recognition that every individual is unique, meaning their therapeutic requirements will differ. We actively listen to our clients, understanding their concerns, strengths, and aspirations. This enables us to develop tailored therapy plans that address their specific challenges while considering their distinct circumstances and preferences.

Search We Level Up The Most Effective OCD Medication for Treatments & Recovery Resources
  1. National Alliance on Mental Illness (NAMI) – Depression:
  2. MedlinePlus – Depression:
  3. Office on Women’s Health – Depression:
  4. National Suicide Prevention Lifeline – Depression:
  5. U.S. Department of Veterans Affairs – Depression:
  6. National Institute on Aging (NIA) – Depression: